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Browsing by Author "Syn, Wing-Kin"
Now showing items 1-3 of 3
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Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection.
Naggie, Susanna; Swiderska-Syn, Marzena; Choi, Steve; Lusk, Sam; Lan, Audrey; Ferrari, Guido; Syn, Wing-Kin; ... (9 authors) (Open forum infectious diseases, 2018-07)Liver disease is a leading cause of HIV-related mortality. Hepatitis C virus (HCV)-related fibrogenesis is accelerated in the setting of HIV coinfection, yet the mechanisms underlying this aggressive pathogenesis are unclear. ... -
Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
Pereira, Thiago A; Syn, Wing-Kin; Machado, Mariana V; Vidigal, Paula V; Resende, Vivian; Voieta, Izabela; Xie, Guanhua; ... (19 authors) (Clin Sci (Lond), 2015-11)Schistosomiasis is a major cause of portal hypertension worldwide. It associates with portal fibrosis that develops during chronic infection. The mechanisms by which the pathogen evokes these host responses remain unclear. ... -
TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice.
Karaca, Gamze; Swiderska-Syn, Marzena; Xie, Guanhua; Syn, Wing-Kin; Krüger, Leandi; Machado, Mariana Verdelho; Garman, Katherine; ... (12 authors) (PLoS One, 2014)BACKGROUND & AIMS: Pro-inflammatory cytokines are important for liver regeneration after partial hepatectomy (PH). Expression of Fibroblast growth factor-inducible 14 (Fn14), the receptor for TNF-like weak inducer of apoptosis ...