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    • APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1. 

      Sullivan, Patrick; Tachibana, Masaya; Holm, Marie-Louise; Liu, Chia-Chen; Shinohara, Mitsuru; Aikawa, Tomonori; Oue, Hiroshi; ... (15 authors) (The Journal of clinical investigation, 2019-02-11)
      Carrying the ε4 allele of the APOE gene encoding apolipoprotein E (APOE4) markedly increases the risk for late-onset Alzheimer's disease (AD), in which APOE4 exacerbates the brain accumulation and subsequent deposition of ...