Browsing by Author "Tadros, Hanna J"

A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C.

Reinoso, Tyler R; Landim-Vieira, Maicon; Shi, Yun; Johnston, Jamie R; Chase, P Bryant; Parvatiyar, Michelle S; Landstrom, Andrew P; ... (9 authors) (Journal of muscle research and cell motility, 2020-11-11)

Familial cardiomyopathy is an inherited disease that affects the structure and function of heart muscle and has an extreme range of phenotypes. Among the millions of affected individuals, patients with hypertrophic (HCM), ...

Copy Number Variants of Undetermined Significance Are Not Associated with Worse Clinical Outcomes in Hypoplastic Left Heart Syndrome.

Dailey-Schwartz, Andrew L; Tadros, Hanna J; Azamian, Mahshid Sababi; Lalani, Seema R; Morris, Shaine A; Allen, Hugh D; Kim, Jeffrey J; ... (8 authors) (The Journal of pediatrics, 2018-11)

OBJECTIVE:To determine the prevalence, spectrum, and prognostic significance of copy number variants of undetermined significance (cnVUS) seen on chromosomal microarray (CMA) in neonates with hypoplastic left heart syndrome ...

Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes.

Tadros, Hanna J; Life, Chelsea S; Garcia, Gustavo; Pirozzi, Elisa; Jones, Edward G; Datta, Susmita; Parvatiyar, Michelle S; ... (12 authors) (Journal of molecular and cellular cardiology, 2020-05)

INTRODUCTION:Troponin (TNN)-encoded cardiac troponins (Tn) are critical for sensing calcium and triggering myofilament contraction. TNN variants are associated with development of cardiomyopathy; however, recent advances ...