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Browsing by Author "Tedder, Thomas F"
Now showing items 1-2 of 2
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CD20 deficiency in humans results in impaired T cell-independent antibody responses.
(J Clin Invest, 2010-01)CD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs are commonly used for the treatment of B cell malignancies and autoantibody-mediated autoimmune diseases. Despite this the role of CD20 ... -
Successful AAV8 readministration: Suppression of capsid-specific neutralizing antibodies by a combination treatment of bortezomib and CD20 mAb in a mouse model of Pompe disease.
(The journal of gene medicine, 2023-03)<h4>Background</h4>A major challenge to adeno-associated virus (AAV)-mediated gene therapy is the presence of anti-AAV capsid neutralizing antibodies (NAbs), which can block viral vector transduction even at very low titers. ...
