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Browsing by Author "Tsalik, Ephraim L"
Now showing items 1-20 of 57
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A blood-based host gene expression assay for early detection of respiratory viral infection: an index-cluster prospective cohort study.
(The Lancet. Infectious diseases, 2020-09-24)BACKGROUND:Early and accurate identification of individuals with viral infections is crucial for clinical management and public health interventions. We aimed to assess the ability of transcriptomic biomarkers to identify ... -
A community approach to mortality prediction in sepsis via gene expression analysis.
(Nature communications, 2018-02)Improved risk stratification and prognosis prediction in sepsis is a critical unmet need. Clinical severity scores and available assays such as blood lactate reflect global illness severity with suboptimal performance, and ... -
A comparison of host response strategies to distinguish bacterial and viral infection.
(PloS one, 2021-01)<h4>Objectives</h4>Compare three host response strategies to distinguish bacterial and viral etiologies of acute respiratory illness (ARI).<h4>Methods</h4>In this observational cohort study, procalcitonin, a 3-protein panel ... -
A cross-sectional analysis of HIV and hepatitis C clinical trials 2007 to 2010: the relationship between industry sponsorship and randomized study design.
(Trials, 2014-01)<h4>Background</h4>The proportion of clinical research sponsored by industry will likely continue to expand as federal funds for academic research decreases, particularly in the fields of HIV/AIDS and hepatitis C (HCV). ... -
A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection.
(Nature communications, 2018-10-24)The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictors from the early stages of infection. Here we conduct a community-based analysis to determine ... -
A Decade On: Systematic Review of ClinicalTrials.gov Infectious Disease Trials, 2007-2017.
(Open forum infectious diseases, 2019-06)Background:Registration of interventional trials of Food and Drug Administration-regulated drug and biological products and devices became a legal requirement in 2007; the vast majority of these trials are registered in ... -
A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.
(Open Forum Infect Dis, 2016-01)Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores ... -
A host gene expression approach for identifying triggers of asthma exacerbations.
(PloS one, 2019-01)RATIONALE:Asthma exacerbations often occur due to infectious triggers, but determining whether infection is present and whether it is bacterial or viral remains clinically challenging. A diagnostic strategy that clarifies ... -
A miRNA Host Response Signature Accurately Discriminates Acute Respiratory Infection Etiologies.
(Frontiers in microbiology, 2018-01)Background: Acute respiratory infections (ARIs) are the leading indication for antibacterial prescriptions despite a viral etiology in the majority of cases. The lack of available diagnostics to discriminate viral and bacterial ... -
Access to COVID-19 testing by individuals with housing insecurity during the early days of the COVID-19 pandemic in the United States: a scoping review.
(Frontiers in public health, 2023-01)<h4>Introduction</h4>The COVID-19 pandemic focused attention on healthcare disparities and inequities faced by individuals within marginalized and structurally disadvantaged groups in the United States. These individuals ... -
An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility.
(Genome medicine, 2021-05)<h4>Background</h4>While genome-wide associations studies (GWAS) have successfully elucidated the genetic architecture of complex human traits and diseases, understanding mechanisms that lead from genetic variation ... -
An integrated transcriptome and expressed variant analysis of sepsis survival and death.
(Genome Med, 2014)BACKGROUND: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor ... -
Analytical Evaluation of the Abbott RealTime CT/NG Assay for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Rectal and Pharyngeal Swabs.
(The Journal of molecular diagnostics : JMD, 2020-06)Chlamydia trachomatis and Neisseria gonorrhoeae infections in the rectum and pharynx are important extragenital reservoirs of infection. Few assays approved by the US Food and Drug Administration are commercially available ... -
Antibacterial Resistance Leadership Group 2.0: Back to Business.
(Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021-08)In December 2019, the Antibacterial Resistance Leadership Group (ARLG) was awarded funding for another 7-year cycle to support a clinical research network on antibacterial resistance. ARLG 2.0 has 3 overarching research ... -
Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset.
(JAMA network open, 2021-09)<h4>Importance</h4>Currently, there are no presymptomatic screening methods to identify individuals infected with a respiratory virus to prevent disease spread and to predict their trajectory for resource allocation.<h4>... -
Average Weighted Accuracy: Pragmatic Analysis for a Rapid Diagnostics in Categorizing Acute Lung Infections (RADICAL) Study.
(Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020-06)Patient management relies on diagnostic information to identify appropriate treatment. Standard evaluations of diagnostic tests consist of estimating sensitivity, specificity, positive/negative predictive values, likelihood ... -
Blood RNA alternative splicing events as diagnostic biomarkers for infectious disease
(Cell Reports Methods, 2023-01-01)Assays detecting blood transcriptome changes are studied for infectious disease diagnosis. Blood-based RNA alternative splicing (AS) events, which have not been well characterized in pathogen infection, have potential ... -
Candidate genes on murine chromosome 8 are associated with susceptibility to Staphylococcus aureus infection in mice and are involved with Staphylococcus aureus septicemia in humans.
(PloS one, 2017-01)We previously showed that chromosome 8 of A/J mice was associated with susceptibility to S. aureus infection. However, the specific genes responsible for this susceptibility are unknown. Chromosome substitution strain 8 ... -
Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity.
(bioRxiv, 2020-12-05)SARS-CoV-2 infection triggers highly variable host responses and causes varying degrees of illness in humans. We sought to harness the peripheral blood mononuclear cell (PBMC) response over the course of illness to provide ... -
Clinically Adjudicated Reference Standards for Evaluation of Infectious Diseases Diagnostics.
(Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023-03)Lack of a gold standard can present a challenge for evaluation of diagnostic test accuracy of some infectious diseases tests, particularly when the test's accuracy potentially exceeds that of its predecessors. This approach ...
