Now showing items 1-2 of 2

    • Ca2+ channel nanodomains boost local Ca2+ amplitude. 

      Tadross, Michael Raphael; Tsien, RW; Yue, DT (Proc Natl Acad Sci U S A, 2013-09-24)
      Local Ca(2+) signals through voltage-gated Ca(2+) channels (CaVs) drive synaptic transmission, neural plasticity, and cardiac contraction. Despite the importance of these events, the fundamental relationship between flux ...
    • Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression. 

      Li, B; Tadross, Michael Raphael; Tsien, RW (Science, 2016-02-19)
      Voltage-gated CaV1.2 channels (L-type calcium channel α1C subunits) are critical mediators of transcription-dependent neural plasticity. Whether these channels signal via the influx of calcium ion (Ca(2+)), voltage-dependent ...