Browsing by Author "Waldman, Todd"

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IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain.

Lopez, Giselle Y; Reitman, Zachary J; Solomon, David; Waldman, Todd; Bigner, Darell D; McLendon, Roger E; Rosenberg, Steven A; ... (9 authors) (Biochemical and biophysical research communications, 2010-07-13)

Isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are enzymes which convert isocitrate to alpha-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+to NADPH). IDH1/2 were ...