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Browsing by Author "Walsh, Kyle M"
Now showing items 1-14 of 14
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A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers.
(Carcinogenesis, 2021-10-13)ATM (ataxia-telangiectasia mutated) is an important cell-cycle checkpoint kinase required for cellular response to DNA damage. Activated by DNA double strand breaks, ATM regulates the activities of many downstream proteins ... -
Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.
(Cancer medicine, 2020-11-16)Because the cadherin-mediated signaling pathway promotes cancer progression, we assessed associations between genetic variants in 109 cadherin-related genes and risk of pancreatic cancer (PanC) by using genotyping data from ... -
Associations of novel variants in PIK3C3, INSR and MAP3K4 of the ATM pathway genes with pancreatic cancer risk.
(American journal of cancer research, 2020-01)The ATM serine/threonine kinase (ATM) pathway plays important roles in pancreatic cancer (PanC) development and progression, but the roles of genetic variants of the genes in this pathway in the etiology of PanC are unknown. ... -
Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia
(Oncotarget, 2017-08-01) -
Congenital human cytomegalovirus infection is associated with decreased transplacental IgG transfer efficiency due to maternal hypergammaglobulinemia.
(Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021-07-14)<h4>Background</h4>Placentally-transferred maternal IgG protects against pathogens in early life, yet vertically-transmitted infections can interfere with transplacental IgG transfer. Although human cytomegalovirus (HCMV) ... -
Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans.
(EBioMedicine, 2016-02)BACKGROUND: Genome-wide association studies have identified polymorphisms linked to both smoking exposure and risk of lung cancer. The degree to which lung cancer risk is driven by increased smoking, genetics, or gene-environment ... -
Genetic determinants of childhood and adult height associated with osteosarcoma risk.
(Cancer, 2018-09)BACKGROUND:Although increased height has been associated with osteosarcoma risk in previous epidemiologic studies, to the authors' knowledge the relative contribution of stature during different developmental timepoints ... -
Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.
(Molecular carcinogenesis, 2019-04-17)The liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathway has been identified as a new target for cancer therapy, because it controls the glucose and lipid metabolism in response to alterations in nutrients and ... -
Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer.
(Molecular carcinogenesis, 2020-05-05)Because the peroxisome proliferator-activated receptor (PPAR) signaling pathway is involved in development and progression of pancreatic cancer, we investigated associations between genetic variants of the PPAR pathway genes ... -
Genetic variation associated with childhood and adult stature and risk of MYCN-amplified neuroblastoma.
(Cancer medicine, 2020-11)<h4>Background</h4>Neuroblastoma is the most common pediatric solid tumor. MYCN-amplification is an important negative prognostic indicator and inherited genetic contributions to risk are incompletely understood. Genetic ... -
Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection.
(The Journal of clinical investigation, 2022-08)Human cytomegalovirus (HCMV) is the most common congenital infection and a leading cause of stillbirth, neurodevelopmental impairment, and pediatric hearing loss worldwide. Development of a maternal vaccine or therapeutic ... -
Pleiotropic MLLT10 variation confers risk of meningioma and estrogen-mediated cancers.
(Neuro-oncology advances, 2022-01)<h4>Background</h4>Risk of tumors of the breast, ovary, and meninges has been associated with hormonal factors and with one another. Genome-wide association studies (GWAS) identified a meningioma risk locus on 10p12 near ... -
Potential Functional Variants in SMC2 and TP53 in the AURORA Pathway Genes and Risk of Pancreatic Cancer.
(Carcinogenesis, 2019-02-22)The AURORA pathway participates in mitosis and cell division, and alterations in mitosis and cell division can lead to carcinogenesis. Therefore, genetic variants in the AURORA pathway genes may be associated with susceptibility ... -
Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.
(Cancer science, 2019-06)Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high- and low-penetrance genes have been implicated in PanC, their roles ...
