Browsing by Author "Wang, Donghai"
Now showing items 1-7 of 7
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Control of antiviral innate immune response by protein geranylgeranylation
(Science Advances, 2019-05)<jats:p>The mitochondrial antiviral signaling protein (MAVS) orchestrates host antiviral innate immune response to RNA virus infection. However, how MAVS signaling is controlled to eradicate virus while preventing ... -
Control of the innate immune response by the mevalonate pathway.
(Nat Immunol, 2016-08)Deficiency in mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate, a non-sterol intermediate ... -
IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense.
(The Journal of investigative dermatology, 2017-05)Skin wound repair requires a coordinated program of epithelial cell proliferation and differentiation as well as resistance to invading microbes. However, the factors that trigger epithelial cell proliferation in ... -
Inflammation in Mice Ectopically Expressing Human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T Mutant Proteins
(Journal of Biological Chemistry, 2013-02-15) -
Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions.
(Nature communications, 2019-09-04)Rho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which normally target proteins to membranes for GTP-loading. However, conditional deletion of GGTase-I in mouse macrophages increases GTP-loading ... -
The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
(Nature Immunology, 2007-02) -
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.
(PLoS pathogens, 2016-12-02)Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses ...
