Browsing by Author "Wang, Qianben"
Now showing items 1-6 of 6
-
Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1.
(Oncotarget, 2018-07-27)Mutation of the APC gene occurs in a high percentage of colorectal tumors and is a central event driving tumor initiation in the large intestine. The APC protein performs multiple tumor suppressor functions including negative ... -
Deciphering and targeting host factors to counteract SARS-CoV-2 and coronavirus infections: insights from CRISPR approaches.
(Frontiers in genome editing, 2023-01)Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses depend on host factors for the process of viral infection and replication. A better understanding of the dynamic interplay between viral pathogens ... -
Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model
(Nature Communications, 2022-12)<jats:title>Abstract</jats:title><jats:p>Knowledge gaps remain on how nucleosome organization and dynamic reorganization are governed by specific pioneer factors in a genome-wide manner. In this study, we generate over three ... -
Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.
(Nucleic acids research, 2018-09)Genomic sequencing of hepatocellular carcinoma (HCC) uncovers a paucity of actionable mutations, underscoring the necessity to exploit epigenetic vulnerabilities for therapeutics. In HCC, EZH2-mediated H3K27me3 represents ... -
Molecular determinants for enzalutamide-induced transcription in prostate cancer.
(Nucleic acids research, 2019-11)Enzalutamide, a second-generation androgen receptor (AR) antagonist, has demonstrated clinical benefit in men with prostate cancer. However, it only provides a temporary response and modest increase in survival, indicating ... -
RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axis.
(The Journal of clinical investigation, 2023-03)Inactivation of the RB1 tumor suppressor gene is common in several types of therapy-resistant cancers, including metastatic castration-resistant prostate cancer, and predicts poor clinical outcomes. Effective therapeutic ...
