Browsing by Author "Wang, Shuyi"
Now showing items 1-5 of 5
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Elucidation of hepatitis C virus transmission and early diversification by single genome sequencing.
(PLoS Pathog, 2012)A precise molecular identification of transmitted hepatitis C virus (HCV) genomes could illuminate key aspects of transmission biology, immunopathogenesis and natural history. We used single genome sequencing of 2,922 half ... -
Microbial Impacts of Selected Pharmaceutically Active Compounds Found in Domestic Wastewater Treatment Plants
(2009)Large amounts of human pharmaceutical products are consumed worldwide. Many drugs and their metabolites, referred to as pharmaceutically active compounds (PhACs), are not fully metabolized prior to household discharge resulting ... -
New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure.
(Journal of virology, 2021-03-03)Previously, we showed that substitution of HIV-1 Env residue 375-Ser by bulky aromatic residues enhances binding to rhesus CD4 and enables primary HIV-1 Envs to support efficient replication as simian-human immunodeficiency ... -
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
(Science (New York, N.Y.), 2020-11-19)Neutralizing antibodies elicited by HIV-1 coevolve with viral envelope proteins (Env) in distinctive patterns, in some cases acquiring substantial breadth. We report that primary HIV-1 envelope proteins-when expressed by ... -
Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing.
(PLoS One, 2010-08-20)We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during ...
