Browsing by Author "Wang, Zheng"

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Genetic Analysis of the Interplay between the Anchor Cell and its Microenvironment during Invasion through Basement Membrane in C. elegans

Wang, Zheng (2013)

Basement membrane (BM) is a dense, conserved sheet-like extracellular matrix that provides structural support, compartmentalizes tissues, and regulates cell behaviors. Despite the barrier-like properties of BM, cell invasion ...
UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity.

Wang, Zheng; Linden, Lara M; Naegeli, Kaleb M; Ziel, Joshua W; Chi, Qiuyi; Hagedorn, Elliott J; Savage, Natasha S; ... (8 authors) (J Cell Biol, 2014-09-01)

The receptor deleted in colorectal cancer (DCC) directs dynamic polarizing activities in animals toward its extracellular ligand netrin. How DCC polarizes toward netrin is poorly understood. By performing live-cell imaging ...