Browsing by Author "Ware, Kathryn E"

Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.

Patierno, Brendon M; Foo, Wen-Chi; Allen, Tyler; Somarelli, Jason A; Ware, Kathryn E; Gupta, Santosh; Wise, Sandra; ... (24 authors) (Prostate cancer and prostatic diseases, 2021-10-13)

<h4>Background</h4>Prostate cancer is a clinically and molecularly heterogeneous disease, with highest incidence and mortality among men of African ancestry. To date, prostate cancer patient-derived xenograft (PCPDX) models ...

Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.

Somarelli, Jason A; Shetler, Samantha; Jolly, Mohit K; Wang, Xueyang; Bartholf Dewitt, Suzanne; Hish, Alexander J; Gilja, Shivee; ... (12 authors) (Mol Cell Biol, 2016-10-01)

Phenotypic plasticity involves a process in which cells transiently acquire phenotypic traits of another lineage. Two commonly studied types of phenotypic plasticity are epithelial-mesenchymal transition (EMT) and ...

Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.

Ware, Kathryn E; Somarelli, Jason A; Schaeffer, Daneen; Li, Jing; Zhang, Tian; Park, Sally; Patierno, Steven R; ... (11 authors) (Oncotarget, 2016-08-02)

Treatment with androgen-targeted therapies can induce upregulation of epithelial plasticity pathways. Epithelial plasticity is known to be important for metastatic dissemination and therapeutic resistance. The goal of this ...