Browsing by Author "Wehrens, XHT"
Now showing items 1-11 of 11
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Calcium Signaling and Cardiac Arrhythmias.
(Circulation research, 2017-06)There has been a significant progress in our understanding of the molecular mechanisms by which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of inherited gene defects can cause potentially ... -
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
(Circulation, 2011-03)Excitation-contraction coupling in striated muscle requires proper communication of plasmalemmal voltage-activated Ca2+ channels and Ca2+ release channels on sarcoplasmic reticulum within junctional membrane complexes. Although ... -
Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases.
(Cardiovascular research, 2014-07)Cardiomyocytes rely on a highly specialized subcellular architecture to maintain normal cardiac function. In a little over a decade, junctophilin-2 (JPH2) has become recognized as a cardiac structural protein critical in ... -
It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias.
(Heart rhythm, 2015-11) -
Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling.
(Heart rhythm, 2016-03) -
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
(Circulation. Heart failure, 2011-03)Junctophilin-2 (JPH2), a protein expressed in the junctional membrane complex, is necessary for proper intracellular calcium (Ca(2+)) signaling in cardiac myocytes. Downregulation of JPH2 expression in a model of cardiac ... -
Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.
(Cardiovascular research, 2013-10)AIMS:Transverse tubules (TTs) provide the basic subcellular structures that facilitate excitation-contraction (EC) coupling, the essential process that underlies normal cardiac contractility. Previous studies have shown ... -
Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization.
(Journal of the American College of Cardiology, 2013-11)This study sought to study the role of junctophilin-2 (JPH2) in atrial fibrillation (AF).JPH2 is believed to have an important role in sarcoplasmic reticulum (SR) Ca(2+) handling and modulation of ryanodine receptor Ca(2+) ... -
Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction.
(JACC. Basic to translational science, 2017-02)BACKGROUND:Hypertrophic cardiomyopathy (HCM), defined as asymmetric left ventricular hypertrophy, is a leading cause of cardiac death in the young. Perturbations in calcium (Ca2+) handling proteins have been implicated in ... -
Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.
(American journal of physiology. Heart and circulatory physiology, 2014-11)Expression silencing of junctophilin-2 (JPH2) in mouse heart leads to ryanodine receptor type 2 (RyR2)-mediated sarcoplasmic reticulum (SR) Ca(2+) leak and rapid development of heart failure. The mechanism and physiological ... -
The junctophilin family of proteins: from bench to bedside.
(Trends in molecular medicine, 2014-06)Excitable tissues rely on junctional membrane complexes to couple cell surface signals to intracellular channels. The junctophilins have emerged as a family of proteins critical in coordinating the maturation and maintenance ...
