Browsing by Author "Weinshilboum, Richard M"
Now showing items 1-5 of 5
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Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression.
MahmoudianDehkordi, Siamak; Ahmed, Ahmed T; Bhattacharyya, Sudeepa; Han, Xianlin; Baillie, Rebecca A; Arnold, Matthias; Skime, Michelle K; ... (21 authors) (Translational psychiatry, 2021-03-02)Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder (MDD), yet their mechanisms of action are not fully understood and their therapeutic benefit varies among individuals. ... -
Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients.
Bhattacharyya, Sudeepa; Ahmed, Ahmed T; Arnold, Matthias; Liu, Duan; Luo, Chunqiao; Zhu, Hongjie; Mahmoudiandehkordi, Siamak; ... (16 authors) (Translational psychiatry, 2019-07-04)Metabolomics provides valuable tools for the study of drug effects, unraveling the mechanism of action and variation in response due to treatment. In this study we used electrochemistry-based targeted metabolomics to gain ... -
Pharmacogenomics-Driven Prediction of Antidepressant Treatment Outcomes: A Machine-Learning Approach With Multi-trial Replication.
Athreya, Arjun P; Neavin, Drew; Carrillo-Roa, Tania; Skime, Michelle; Biernacka, Joanna; Frye, Mark A; Rush, A John; ... (12 authors) (Clinical pharmacology and therapeutics, 2019-10)We set out to determine whether machine learning-based algorithms that included functionally validated pharmacogenomic biomarkers joined with clinical measures could predict selective serotonin reuptake inhibitor (SSRI) ... -
Pilot Study of Metabolomic Clusters as State Markers of Major Depression and Outcomes to CBT Treatment.
Bhattacharyya, Sudeepa; Dunlop, Boadie W; Mahmoudiandehkordi, Siamak; Ahmed, Ahmed T; Louie, Gregory; Frye, Mark A; Weinshilboum, Richard M; ... (12 authors) (Frontiers in neuroscience, 2019-01)Major depressive disorder (MDD) is a common and disabling syndrome with multiple etiologies that is defined by clinically elicited signs and symptoms. In hopes of developing a list of candidate biological measures that reflect ... -
Prediction of short-term antidepressant response using probabilistic graphical models with replication across multiple drugs and treatment settings.
Athreya, Arjun P; Brückl, Tanja; Binder, Elisabeth B; John Rush, A; Biernacka, Joanna; Frye, Mark A; Neavin, Drew; ... (17 authors) (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021-06)Heterogeneity in the clinical presentation of major depressive disorder and response to antidepressants limits clinicians' ability to accurately predict a specific patient's eventual response to therapy. Validated depressive ...