Browsing by Author "Wischmeyer, Paul E"
Now showing items 1-18 of 18
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A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial.
(Crit Care, 2017-06-09)BACKGROUND: Nutrition guidelines recommendations differ on the use of parenteral nutrition (PN), and existing clinical trial data are inconclusive. Our recent observational data show that amounts of energy/protein received ... -
American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Nutrition Screening and Therapy Within a Surgical Enhanced Recovery Pathway.
(Anesth Analg, 2018-01-23)Perioperative malnutrition has proven to be challenging to define, diagnose, and treat. Despite these challenges, it is well known that suboptimal nutritional status is a strong independent predictor of poor postoperative ... -
American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Patient-Reported Outcomes in an Enhanced Recovery Pathway.
(Anesthesia and analgesia, 2018-06)Patient-reported outcomes (PROs) are measures of health status that come directly from the patient. PROs are an underutilized tool in the perioperative setting. Enhanced recovery pathways (ERPs) have primarily focused on ... -
American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Postoperative Gastrointestinal Dysfunction Within an Enhanced Recovery Pathway for Elective Colorectal Surgery.
(Anesthesia and analgesia, 2018-06)The primary driver of length of stay after bowel surgery, particularly colorectal surgery, is the time to return of gastrointestinal (GI) function. Traditionally, delayed GI recovery was thought to be a routine and unavoidable ... -
Are we creating survivors…or victims in critical care? Delivering targeted nutrition to improve outcomes.
(Curr Opin Crit Care, 2016-08) -
Assessments of frailty in bladder cancer.
(Urologic oncology, 2020-05-22)BACKGROUND AND AIMS:The incidence of frailty is increasing as the population ages, which has important clinical implications given the associations between frailty and poor outcomes in the bladder cancer population. Due ... -
Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in IL-1/LPS-Insufflated Rats.
(PLoS One, 2015)BACKGROUND: Glutamine (GLN) attenuates acute lung injury (ALI) but its effect on alveolar macrophages is unknown. We hypothesized that GLN pretreatment would induce the anti-inflammatory CD163/heme oxygenase (HO)-1/p38-MAPK ... -
Clinical review: Optimizing enteral nutrition for critically ill patients--a simple data-driven formula.
(Crit Care, 2011)In modern critical care, the paradigm of 'therapeutic nutrition' is replacing traditional 'supportive nutrition'. Standard enteral formulas meet basic macro- and micronutrient needs; therapeutic enteral formulas meet these ... -
Early propranolol treatment induces lung heme-oxygenase-1, attenuates metabolic dysfunction, and improves survival following experimental sepsis.
(Crit Care, 2013-09-10)INTRODUCTION: Pharmacological agents that block beta-adrenergic receptors have been associated with improved outcome in burn injury. It has been hypothesized that injuries leading to a hypermetabolic state, such as septic ... -
Extracorporeal membrane oxygenation postcardiotomy: "With great power comes great responsibility".
(J Thorac Cardiovasc Surg, 2017-01) -
Immediate Post-operative Enterocyte Injury, as Determined by Increased Circulating Intestinal Fatty Acid Binding Protein, Is Associated With Subsequent Development of Necrotizing Enterocolitis After Infant Cardiothoracic Surgery.
(Frontiers in pediatrics, 2020-01)Objectives: 1 Measure serial serum intestinal fatty acid binding protein levels in infants undergoing cardiac surgery with cardiopulmonary bypass to evaluate for evidence of early post-operative enterocyte injury. 2 Determine ... -
Impact of early postoperative oral nutritional supplement utilization on clinical outcomes in colorectal surgery.
(Perioperative medicine (London, England), 2020-01)Background:Small randomized trials of early postoperative oral nutritional supplementation (ONS) suggest various health benefits following colorectal surgery (CRS). However, real-world evidence of the impact of early ONS ... -
Novel approaches to metabolic assessment and structured exercise to promote recovery in ICU survivors
(Current Opinion in Critical Care, 2020-06-19) -
Persistent hypermetabolism and longitudinal energy expenditure in critically ill patients with COVID-19.
(Critical care (London, England), 2020-09-28) -
Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis.
(Crit Care, 2016-08-19)BACKGROUND: Critical illness is characterized by a loss of commensal flora and an overgrowth of potentially pathogenic bacteria, leading to a high susceptibility to nosocomial infections. Probiotics are living non-pathogenic ... -
Role of the microbiome, probiotics, and 'dysbiosis therapy' in critical illness.
(Curr Opin Crit Care, 2016-08)PURPOSE OF REVIEW: Loss of 'health-promoting' microbes and overgrowth of pathogenic bacteria (dysbiosis) in ICU is believed to contribute to nosocomial infections, sepsis, and organ failure (multiple organ dysfunction syndrome). ... -
Tailoring nutrition therapy to illness and recovery.
(Crit Care, 2017-12-28)Without doubt, in medicine as in life, one size does not fit all. We do not administer the same drug or dose to every patient at all times, so why then would we live under the illusion that we should give the same nutrition ...
