Browsing by Author "Xu, Li"
Now showing items 1-6 of 6
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A cord blood monocyte-derived cell therapy product accelerates brain remyelination.
(JCI insight, 2016-08-18)Microglia and monocytes play important roles in regulating brain remyelination. We developed DUOC-01, a cell therapy product intended for treatment of demyelinating diseases, from banked human umbilical cord blood ... -
Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer.
(PloS one, 2012-01)p53 and p73 interact with human papillomavirus (HPV) E6 and E7 oncoproteins. The interplay between p53 and p73 and HPV16 may lead to deregulation of cell cycle and apoptosis, through which inflammation/immune responses control ... -
Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.
(Molecular cancer, 2012-03-26)Cell cycle deregulation is common in human cancer, and alterations of p27 and p21, two critical cell cycle regulators, have been implicated in the development of many human malignancies. Therefore, we hypothesize that p27 ... -
Genetic variation in MDM2 and p14ARF and susceptibility to salivary gland carcinoma.
(PloS one, 2012-01)The p14(ARF)/MDM2/p53 pathway plays an important role in modulation of DNA damage and oxidative stress responses. The aim of this study was to determine whether genetic variants in MDM2 and p14(ARF) are associated with risk ... -
Human umbilical cord blood monocytes, but not adult blood monocytes, rescue brain cells from hypoxic-ischemic injury: Mechanistic and therapeutic implications.
(PloS one, 2019-01)Cord blood (CB) mononuclear cells (MNC) are being tested in clinical trials to treat hypoxic-ischemic (HI) brain injuries. Although early results are encouraging, mechanisms underlying potential clinical benefits are not ... -
Mesenchymal stromal cells reprogram monocytes and macrophages with processing bodies.
(Stem cells (Dayton, Ohio), 2021-01)Mesenchymal stromal cells (MSCs) are widely used in clinical trials because of their ability to modulate inflammation. The success of MSCs has been variable over 25 years, most likely due to an incomplete understanding of ...
