Browsing by Author "Yan, Dong"
Now showing items 1-5 of 5
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An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection.
(Neuron, 2018-01-03)Infections have been identified as possible risk factors for aging-related neurodegenerative diseases, but it remains unclear whether infection-related immune molecules have a causative role in neurodegeneration during aging. ... -
Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform.
(Neuron, 2012-11-08)MAPKKK dual leucine zipper-bearing kinases (DLKs) are regulators of synaptic development and axon regeneration. The mechanisms underlying their activation are not fully understood. Here, we show that C. elegans DLK-1 is ... -
Robo functions as an attractive cue for glial migration through SYG-1/Neph.
(eLife, 2020-11-19)As one of the most-studied receptors, Robo plays functions in many biological processes, and its functions highly depend on Slit, the ligand of Robo. Here we uncover a Slit-independent role of Robo in glial migration and ... -
The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons
(Cell Reports, 2015-01-01)© 2015 The Authors. Synapse elimination occurs in development, plasticity, and disease. Although the importance of synapse elimination has been documented in many studies, the molecular mechanisms underlying this process ... -
The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
(Cell, 2009-09-04)Growth cone guidance and synaptic plasticity involve dynamic local changes in proteins at axons and dendrites. The Dual-Leucine zipper Kinase MAPKKK (DLK) has been previously implicated in synaptogenesis and axon outgrowth ...
