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Browsing by Author "Yashin, Anatoliy I"
Now showing items 1-20 of 38
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A new algorithm for predicting time to disease endpoints in Alzheimer's disease patients.
(J Alzheimers Dis, 2014)BACKGROUND: The ability to predict the length of time to death and institutionalization has strong implications for Alzheimer's disease patients and caregivers, health policy, economics, and the design of intervention studies. ... -
Age patterns of incidence of geriatric disease in the U.S. elderly population: Medicare-based analysis.
(J Am Geriatr Soc, 2012-02)OBJECTIVES: To use the Medicare Files of Service Use (MFSU) to evaluate patterns in the incidence of aging-related diseases in the U.S. elderly population. DESIGN: Age-specific incidence rates of 19 aging-related diseases ... -
Age trajectories of physiological indices in relation to healthy life course.
(Mech Ageing Dev, 2011-03)We analysed relationship between the risk of onset of "unhealthy life" (defined as the onset of cancer, cardiovascular diseases, or diabetes) and longitudinal changes in body mass index, diastolic blood pressure, hematocrit, ... -
Aging and health--a systems biology perspective. Introduction.
(Interdiscip Top Gerontol, 2015) -
An age-structured extension to the vectorial capacity model.
(PLoS One, 2012)BACKGROUND: Vectorial capacity and the basic reproductive number (R(0)) have been instrumental in structuring thinking about vector-borne pathogen transmission and how best to prevent the diseases they cause. One of the ... -
Biodemographic Analyses of Longitudinal Data on Aging, Health, and Longevity: Recent Advances and Future Perspectives.
(Adv Geriatr, 2017-06-02)Biodemography became one of the most innovative and fastest growing areas in demography. This progress is fueled by the growing variability and amount of relevant data available for analyses as well as by methodological ... -
Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.
(J Gerontol A Biol Sci Med Sci, 2013-07)This study focuses on the participants of the Long Life Family Study to elucidate whether biogenetic mechanisms underlying relationships among heritable complex phenotypes in parents function in the same way for the same ... -
Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.
(PLoS One, 2015)Insights into genetic origin of diseases and related traits could substantially impact strategies for improving human health. The results of genome-wide association studies (GWAS) are often positioned as discoveries ... -
Dynamics of biomarkers in relation to aging and mortality.
(Mech Ageing Dev, 2016-06)Contemporary longitudinal studies collect repeated measurements of biomarkers allowing one to analyze their dynamics in relation to mortality, morbidity, or other health-related outcomes. Rich and diverse data collected ... -
Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging.
(Scientifica (Cairo), 2012)We evaluated effects of the APOE polymorphism (carriers versus noncarriers of the e4 allele) and age trajectories of total cholesterol (CH) and diastolic blood pressure (DBP) on mortality risk in the Framingham Heart Study ... -
Epidemiology of geographic disparities in heart failure among US older adults: a Medicare-based analysis.
(BMC public health, 2022-07)<h4>Background</h4>There are prominent geographic disparities in the life expectancy (LE) of older US adults between the states with the highest (leading states) and lowest (lagging states) LE and their causes remain poorly ... -
Estimation and validation of a multiattribute model of Alzheimer disease progression.
(Med Decis Making, 2010-11)OBJECTIVES: To estimate and validate a multiattribute model of the clinical course of Alzheimer disease (AD) from mild AD to death in a high-quality prospective cohort study, and to estimate the impact of hypothetical ... -
Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal data.
(Biogerontology, 2011-04)Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease ... -
Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency.
(Sci Rep, 2016-10-14)Common strategy of genome-wide association studies (GWAS) relying on large samples faces difficulties, which raise concerns that GWAS have exhausted their potential, particularly for complex traits. Here, we examine the ... -
Genetic Structures of Population Cohorts Change with Increasing Age: Implications for Genetic Analyses of Human aging and Life Span.
(Ann Gerontol Geriatr Res, 2017-06-02)BACKGROUND: Correcting for the potential effects of population stratification is an important issue in genome wide association studies (GWAS) of complex traits. Principal component analysis (PCA) of the genetic structure ... -
Genetics of aging, health, and survival: dynamic regulation of human longevity related traits.
(Front Genet, 2015)BACKGROUND: The roles of genetic factors in human longevity would be better understood if one can use more efficient methods in genetic analyses and investigate pleiotropic effects of genetic variants on aging and health ... -
How genes influence life span: the biodemography of human survival.
(Rejuvenation Res, 2012-08)BACKGROUND: In genome-wide association studies (GWAS) of human life span, none of the genetic variants has reached the level of genome-wide statistical significance. The roles of such variants in life span regulation remain ... -
How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.
(N Am Actuar J, 2016)BACKGROUND AND OBJECTIVE: To clarify mechanisms of genetic regulation of human aging and longevity traits, a number of genome-wide association studies (GWAS) of these traits have been performed. However, the results of these ... -
How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.
(Front Genet, 2013)BACKGROUND AND OBJECTIVE: The influence of genes on human lifespan is mediated by biological processes that characterize body's functioning. The age trajectories of these processes contain important information about mechanisms ... -
How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.
(Biogerontology, 2016-02)Increasing proportions of elderly individuals in developed countries combined with substantial increases in related medical expenditures make the improvement of the health of the elderly a high priority today. If the process ...
