Browsing by Author "Yi, John S"
Now showing items 1-11 of 11
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A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection
(Science, 2009-06-19) -
B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.
(Front Neurol, 2017)Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated disease. The mechanisms for loss of self-tolerance in this disease are not well understood, and recently described regulatory B cell (Breg) subsets have not been ... -
Characterization of B cells in muscle-specific kinase antibody myasthenia gravis.
(Neurol Neuroimmunol Neuroinflamm, 2015-04)OBJECTIVE: To characterize B-cell subsets in patients with muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG). METHODS: In accordance with Human Immunology Project Consortium guidelines, we performed polychromatic ... -
Characterizing the Switching Thresholds of Magnetophoretic Transistors.
(Adv Mater, 2015-10-28)The switching thresholds of magnetophoretic transistors for sorting cells in microfluidic environments are characterized. The transistor operating conditions require short 20-30 mA pulses of electrical current. By demonstrating ... -
Establishment of normative ranges of the healthy human immune system with comprehensive polychromatic flow cytometry profiling.
(PloS one, 2019-01)Existing normative flow cytometry data have several limitations including small sample sizes, incompletely described study populations, variable flow cytometry methodology, and limited depth for defining lymphocyte ... -
Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.
(PLoS Pathog, 2011-09)During many chronic infections virus-specific CD8 T cells succumb to exhaustion as they lose their ability to respond to antigenic activation. Combinations of IL-12, IL-18, and IL-21 have been shown to induce the ... -
Interleukin-21: a multifunctional regulator of immunity to infections
(Microbes and Infection, 2010-12) -
Normative dataset for plasma cytokines in healthy human adults.
(Data in brief, 2021-04)We determined normative data for plasma cytokines established from a cohort of 126 carefully screened healthy adults aged 18 to 64 years. Participants were enrolled to ensure an even age and sex distribution and to include ... -
Prolonged B-cell depletion in MuSK myasthenia gravis following rituximab treatment.
(Muscle Nerve, 2013-12) -
Successful AAV8 readministration: Suppression of capsid-specific neutralizing antibodies by a combination treatment of bortezomib and CD20 mAb in a mouse model of Pompe disease.
(The journal of gene medicine, 2023-03)<h4>Background</h4>A major challenge to adeno-associated virus (AAV)-mediated gene therapy is the presence of anti-AAV capsid neutralizing antibodies (NAbs), which can block viral vector transduction even at very low titers. ... -
T-cell exhaustion: characteristics, causes and conversion
(Immunology, 2010-04)
