Now showing items 1-4 of 4

    • Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration. 

      Shenolikar, Shirish; Goh, Catherine Wenhui; Lee, Irene Chengjie; Sundaram, Jeyapriya Rajameenakshi; George, Simi Elizabeth; Yusoff, Permeen; Brush, Matthew Hayden; ... (8 authors) (The Journal of biological chemistry, 2018-01)
      Oxidative and endoplasmic reticulum (ER) stresses are hallmarks of the pathophysiology of ALS and other neurodegenerative diseases. In these stresses, different kinases phosphorylate eukaryotic initiation factor eIF2α, enabling ...
    • Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function. 

      Shenolikar, Shirish; Lee, Irene Chengjie; Ho, Xue Yan; George, Simi Elizabeth; Goh, Catherine Wenhui; Sundaram, Jeyapriya Rajameenakshi; Pang, Karen Ka Lam; ... (10 authors) (Cell death and differentiation, 2018-02)
      Phosphorylation of the eukaryotic translation initiation factor, eIF2α, by stress-activated protein kinases and dephosphorylation by the growth arrest and DNA damage-inducible protein (GADD34)-containing phosphatase is a ...
    • Phosphorylation at tyrosine 262 promotes GADD34 protein turnover. 

      Jeyaraman, Krishna; Shenolikar, Shirish; Yusoff, Permeen; Zhou, Wei (The Journal of biological chemistry, 2013-11)
      In mammalian cells, metabolic and environmental stress increases the phosphorylation of the eukaryotic translational initiation factor, eIF2α, and attenuates global protein synthesis. Subsequent transcriptional activation ...
    • Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase. 

      Choy, Meng S; Goh, Catherine W; Lee, Irene C; Newton, Jocelyn C; Page, Rebecca; Peti, Wolfgang; Shenolikar, Shirish; ... (8 authors) (Cell reports, 2015-06-18)
      The attenuation of protein synthesis via the phosphorylation of eIF2α is a major stress response of all eukaryotic cells. The growth-arrest- and DNA-damage-induced transcript 34 (GADD34) bound to the serine/threonine protein ...