Now showing items 1-3 of 3

    • Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. 

      Chen, Chen; Zhang, Liguo; Huang, Nai-Jia; Huang, Bofu; Kornbluth, Sally (Proc Natl Acad Sci U S A, 2013-12-17)
      Ataxia telangiectasia mutant (ATM) is an S/T-Q-directed kinase that is critical for the cellular response to double-stranded breaks (DSBs) in DNA. Following DNA damage, ATM is activated and recruited by the MRN protein complex ...
    • The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. 

      Huang, Nai-Jia; Zhang, Liguo; Tang, Wanli; Chen, Chen; Yang, Chih-Sheng; Kornbluth, Sally (J Cell Biol, 2012-04-30)
      Proapoptotic Bcl-2 family members, such as Bax, promote release of cytochrome c from mitochondria, leading to caspase activation and cell death. It was previously reported that modulator of apoptosis protein 1 (MOAP-1), ...
    • Ubiquitylation of p53 by the APC/C inhibitor Trim39. 

      Zhang, Liguo; Huang, Nai-Jia; Chen, Chen; Tang, Wanli; Kornbluth, Sally (Proc Natl Acad Sci U S A, 2012-12-18)
      Tripartite motif 39 (Trim39) is a RING domain-containing E3 ubiquitin ligase able to inhibit the anaphase-promoting complex (APC/C) directly. Through analysis of Trim39 function in p53-positive and p53-negative cells, we ...