Now showing items 1-3 of 3

    • Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature. 

      Petrovski, Slavé; Parrott, Roberta E; Roberts, Joseph L; Huang, Hongxiang; Yang, Jialong; Gorentla, Balachandra; Mousallem, Talal; ... (14 authors) (J Clin Immunol, 2016-07)
      The purpose of this research was to use next generation sequencing to identify mutations in patients with primary immunodeficiency diseases whose pathogenic gene mutations had not been identified. Remarkably, four unrelated ...
    • Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells. 

      Wang, Hong-Xia; Qiu, Yu-Rong; Zhong, Xiao-Ping (PLoS One, 2016)
      Promiscuous expression of tissue restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is crucial for negative selection of self-reactive T cells to establish central tolerance. Intercellular transfer of ...
    • TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. 

      Ci, Xinxin; Kuraoka, Masayuki; Wang, Hongxia; Carico, Zachary; Hopper, Kristen; Shin, Jinwook; Deng, Xuming; ... (11 authors) (PLoS One, 2015)
      Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR signaling, plays an important role in the immune system. We report here that TSC1 differentially ...