Now showing items 1-5 of 5

    • An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. 

      Chisholm, AD; Chuang, M; E, Lezi; Eroglu, C; Koh, S; Matsunami, Hiroaki; Pujol, N; ... (10 authors) (Neuron, 2018-01-03)
      Infections have been identified as possible risk factors for aging-related neurodegenerative diseases, but it remains unclear whether infection-related immune molecules have a causative role in neurodegeneration during aging. ...
    • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. 

      Alam, S Munir; Boyd, SD; Cai, Fangping; Chen, S; Chen, Y; Cohen, M; Du, X; ... (45 authors) (Nature, 2013-04-25)
      Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected individuals, and details ...
    • Modeling the QBO-Improvements resulting from higher-model vertical resolution. 

      Geller, MA; Zhou, T; Shindell, Drew Todd; Ruedy, R; Aleinov, I; Nazarenko, L; Tausnev, NL; ... (12 authors) (J Adv Model Earth Syst, 2016-09)
      Using the NASA Goddard Institute for Space Studies (GISS) climate model, it is shown that with proper choice of the gravity wave momentum flux entering the stratosphere and relatively fine vertical layering of at least 500 ...
    • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. 

      Arthos, J; Bewley, CA; Bonsignori, Mattia; Boyington, JC; Burton, DR; Carrico, C; Chuang, G-Y; ... (47 authors) (Nature, 2011-11-23)
      Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are themselves protected by extraordinary sequence diversity ...
    • The missense of smell: functional variability in the human odorant receptor repertoire. 

      Adipietro, KA; Keller, A; Lee, SS; Li, YR; Lin, A; Liu, WL; Mainland, JD; ... (14 authors) (Nat Neurosci, 2014-01)
      Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms ...