Now showing items 1-3 of 3

    • An integrated transcriptome and expressed variant analysis of sepsis survival and death. 

      Tsalik, Ephraim L; Langley, Raymond J; Dinwiddie, Darrell L; Miller, Neil A; Yoo, Byunggil; van Velkinburgh, Jennifer C; Smith, Laurie D; ... (24 authors) (Genome Med, 2014)
      BACKGROUND: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor ...
    • Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. 

      Ahn, Sun Hee; Tsalik, Ephraim L; Cyr, Derek D; Zhang, Yurong; van Velkinburgh, Jennifer C; Langley, Raymond J; Glickman, Seth W; ... (18 authors) (PLoS One, 2013)
      Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the ...
    • Renal systems biology of patients with systemic inflammatory response syndrome. 

      Tsalik, Ephraim L; Willig, Laurel K; Rice, Brandon J; van Velkinburgh, Jennifer C; Mohney, Robert P; McDunn, Jonathan E; Dinwiddie, Darrell L; ... (21 authors) (Kidney Int, 2015-10)
      A systems biology approach was used to comprehensively examine the impact of renal disease and hemodialysis (HD) on patient response during critical illness. To achieve this, we examined the metabolome, proteome, ...