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Early Physiological and Cellular Indicators of Cisplatin-Induced Ototoxicity.
(Journal of the Association for Research in Otolaryngology : JARO, 2021-04)Cisplatin chemotherapy often causes permanent hearing loss, which leads to a multifaceted decrease in quality of life. Identification of early cisplatin-induced cochlear damage would greatly improve clinical diagnosis and ... -
Detecting Cochlear Synaptopathy Through Curvature Quantification of the Auditory Brainstem Response.
(Frontiers in cellular neuroscience, 2022-01)The sound-evoked electrical compound potential known as auditory brainstem response (ABR) represents the firing of a heterogenous population of auditory neurons in response to sound stimuli, and is often used for clinical ... -
Optimizing non-invasive functional markers for cochlear deafferentation based on electrocochleography and auditory brainstem responses.
(The Journal of the Acoustical Society of America, 2022-04)Accumulating evidence suggests that cochlear deafferentation may contribute to suprathreshold deficits observed with or without elevated hearing thresholds, and can lead to accelerated age-related hearing loss. Currently ... -
Integrating pharmacogenomics into clinical trials of hearing disorders.
(The Journal of the Acoustical Society of America, 2022-11)In 2019, the U.S. Food and Drug Administration issued guidance to increase the efficiency of drug development and support precision medicine, including tailoring treatments to those patients who will benefit based on genetic ... -
Noise-induced hearing disorders: Clinical and investigational tools.
(The Journal of the Acoustical Society of America, 2023-01)A series of articles discussing advanced diagnostics that can be used to assess noise injury and associated noise-induced hearing disorders (NIHD) was developed under the umbrella of the United States Department of Defense ... -
Mechanical circulatory support for end-stage heart failure in repaired and palliated congenital heart disease.
(Current cardiology reviews, 2011-05)Approximately one in one hundred children is born with congenital heart disease. Most can be managed with corrective or palliative surgery but a small group will develop severe heart failure, leaving cardiac transplantation ... -
Chronic in vivo testing of the Penn State infant ventricular assist device.
(ASAIO journal (American Society for Artificial Internal Organs : 1992), 2012-01)The Penn State Infant Ventricular Assist Device (VAD) is a 12-14 ml stroke volume pneumatically actuated pump, with custom Björk-Shiley monostrut valves, developed under the National Heart, Lung, and Blood Institute Pediatric ... -
Anomalous Origin of the Right Coronary Artery from the Pulmonary Artery in a Neonate with Turner Syndrome and Aortic Arch Hypoplasia.
(Texas Heart Institute journal, 2019-06)Anomalous origin of the right coronary artery from the pulmonary artery, a rare congenital cardiac defect, is typically not diagnosed during infancy. On the other hand, Turner syndrome is usually diagnosed early, and it ... -
Identifying inequities in lung transplantation: a call for strategies and future research
(JHLT Open, 2023-12) -
Cellular communication among smooth muscle cells: The role of membrane potential via connexins.
(Journal of theoretical biology, 2023-11)Communication via action potentials among neurons has been extensively studied. However, effective communication without action potentials is ubiquitous in biological systems, yet it has received much less attention ... -
Assessing the nonlinear association of environmental factors with antibiotic resistance genes (ARGs) in the Yangtze River Mouth, China.
(Scientific reports, 2023-11)The emergence of antibacterial resistance (ABR) is an urgent and complex public health challenge worldwide. Antibiotic resistant genes (ARGs) are considered as a new pollutant by the WHO because of their wide distribution ... -
A 15-year consolidated overview of data in over 6000 patients from the Transthyretin Amyloidosis Outcomes Survey (THAOS).
(Orphanet journal of rare diseases, 2023-11)<h4>Background</h4>Transthyretin amyloidosis (ATTR amyloidosis) is a progressive, multisystemic, life-threatening disease resulting from the deposition of variant or wild-type (ATTRwt amyloidosis) transthyretin amyloid fibrils ... -
Improved AlphaFold modeling with implicit experimental information.
(Nature methods, 2022-11)Machine-learning prediction algorithms such as AlphaFold and RoseTTAFold can create remarkably accurate protein models, but these models usually have some regions that are predicted with low confidence or poor accuracy. ... -
Accelerating crystal structure determination with iterative AlphaFold prediction.
(Acta crystallographica. Section D, Structural biology, 2023-03)Experimental structure determination can be accelerated with artificial intelligence (AI)-based structure-prediction methods such as AlphaFold. Here, an automatic procedure requiring only sequence information and crystallographic ... -
The importance of residue-level filtering and the Top2018 best-parts dataset of high-quality protein residues.
(Protein science : a publication of the Protein Society, 2022-01)We have curated a high-quality, "best-parts" reference dataset of about 3 million protein residues in about 15,000 PDB-format coordinate files, each containing only residues with good electron density support for a physically ... -
Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype.
(Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023-11)The essential branched-chain amino acids (BCAAs) leucine, isoleucine, and valine play critical roles in protein synthesis and energy metabolism. Despite their widespread use as nutritional supplements, BCAAs' full effects ... -
Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing.
(Cell research, 2023-07)Cellular senescence is a stress-induced, stable cell cycle arrest phenotype which generates a pro-inflammatory microenvironment, leading to chronic inflammation and age-associated diseases. Determining the fundamental molecular ... -
Metabolic factors associated with incident fracture among older adults with type 2 diabetes mellitus: a nested case-control study.
(Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2023-07)Older adults with type 2 diabetes mellitus have an increased risk of fracture despite a paradoxically higher average bone mineral density. This study identified additional markers of fracture risk in this at-risk population. ... -
Nightshift imposes irregular lifestyle behaviors in police academy trainees.
(Sleep advances : a journal of the Sleep Research Society, 2023-01)<h4>Study objective</h4>Shiftwork increases risk for numerous chronic diseases, which is hypothesized to be linked to disruption of circadian timing of lifestyle behaviors. However, empirical data on timing of lifestyle ... -
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease and Transverse Myelitis Probably Associated With SARS-CoV-2 mRNA Vaccines: Two Case Reports.
(The Neurohospitalist, 2022-07)Post-vaccination CNS demyelinating syndromes have been reported with a variety of vaccines including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines. We report a case of myelin oligodendrocyte ...
