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Now showing items 1-20 of 16488
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https://www.intechopen.com/books/cancer-metastasis/genetic-mutations-and-ubiquitination-in-melanoma-growth-and-metastasis
(2019-11-08)Upon neoplastic transformation, melanoma is intrinsically prone to metastasis, which marks the most dangerous aspect of the disease and dubs it one of the most challenging cancers to treat. BRAF/MEK oncokinase inhibitors ... -
Feminism and Avant-Garde Aesthetics in the Levantine Novel, by Kifah Hanna
(Journal of Middle East Women's Studies, 2019-03-01) -
Italian Americans and the Mythology of Crime: “The Godfather Paradox”
(AATI Online Working Papers, 2019-02-03) -
How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways
(Cellular Signalling, 2019-02)© 2018 Elsevier Inc. Chemokines play crucial roles in combating microbial infection and initiating tissue repair by recruiting neutrophils in a timely and coordinated manner. In humans, no less than seven chemokines (CXCL1, ... -
Low-intensity logging and hunting have long-term effects on seed dispersal but not fecundity in Afrotropical forests.
(AoB PLANTS, 2019-02)Hunting and logging, ubiquitous human disturbances in tropical forests, have the potential to alter the ecological processes that govern population recruitment and community composition. Hunting-induced declines in populations ... -
REGULATION OF THALAMIC ACTIVITY FOR CONTROL OF AGGRESSION
(2019-01-31) -
Effectiveness of psychological treatments for depression and alcohol use disorder delivered by community-based counsellors: two pragmatic randomised controlled trials within primary healthcare in Nepal.
(The British journal of psychiatry : the journal of mental science, 2019-01-25)BACKGROUND:Evidence shows benefits of psychological treatments in low-resource countries, yet few government health systems include psychological services.AimEvaluating the clinical value of adding psychological treatments, ... -
Recommendations towards standards for quantitative MRI (qMRI) and outstanding needs.
(Journal of magnetic resonance imaging : JMRI, 2019-01-24)LEVEL OF EVIDENCE:5 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2019. -
Increased predominance of HIV-1 CRF01_AE and its recombinants in the Philippines.
(The Journal of general virology, 2019-01-24)The growth rate of new HIV infections in the Philippines was the fastest of any countries in the Asia-Pacific region between 2010 and 2016. To date, HIV-1 subtyping results in the Philippines have been determined ... -
The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.
(Journal of the American Geriatrics Society, 2019-01-23)BACKGROUND/OBJECTIVES:Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated ... -
Genetic Variants in RUNX3, AMD1 and MSRA in the Methionine Metabolic Pathway and Survival in Non-small Cell Lung Cancer Patients.
(International journal of cancer, 2019-01-16)Abnormal methionine dependence in cancer cells has led to methionine restriction as a potential therapeutic strategy. We hypothesized that genetic variants involved in methionine-metabolic genes are associated with survival ... -
Vaccine-induced memory CD8+ T cells provide clinical benefit in HER2 expressing breast cancer: a mouse to human translational study.
(Clinical cancer research : an official journal of the American Association for Cancer Research, 2019-01-11)PURPOSE:Immune-based therapy for metastatic breast cancer has had limited success, particularly in molecular subtypes with low somatic mutations rates. Strategies to augment T cell infiltration of tumors include vaccines ... -
Low use of routine medical care among African Americans with high CKD risk: the Jackson Heart Study.
(BMC nephrology, 2019-01-10)BACKGROUND:Use of routine medical care (RMC) is advocated to address ethnic/racial disparities in chronic kidney disease (CKD) risks, but use is less frequent among African Americans. Factors associated with low RMC use ... -
Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways.
(Microbial cell (Graz, Austria), 2019-01-07)Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular ... -
MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection.
(Science advances, 2019-01-02)Mast cells (MCs) are strategically distributed at barrier sites and prestore various immunocyte-recruiting cytokines, making them ideal targets for selective activation to treat peripheral infections. Here, we report that ... -
Wide-field whole eye OCT system with demonstration of quantitative retinal curvature estimation
(Biomedical Optics Express, 2019-01-01) -
Pre-operative nutrition and the elective surgical patient: why, how and what?
(Anaesthesia, 2019-01) -
Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury.
(Osteoarthritis and cartilage, 2019-01)OBJECTIVE:There are few guidelines for clinical trials of interventions for prevention of post-traumatic osteoarthritis (PTOA), reflecting challenges in this area. An international multi-disciplinary expert group including ... -
Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes.
(Arthritis research & therapy, 2018-12-27)BACKGROUND:Sarcopenic obesity, associated with greater risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA), may be related to dysregulated muscle remodeling. To determine whether exercise training ...
