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day, December 12.
Browsing by Department "Biomedical Engineering"
Now showing items 1-20 of 470
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3D dynamic in vivo imaging of joint motion: application to measurement of anterior cruciate ligament function
(2019)More than 400,000 anterior cruciate ligament (ACL) injuries occur annually in the United States, 70% of which are non-contact. A severe consequence of ACL injury is the increased risk of early-onset of osteoarthritis (OA). ... -
3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
(2021)Tissue-engineered skeletal muscle presents promising opportunities for developing high-fidelity in vitro models for investigating human muscle biology in the areas of regeneration and disease. In muscle regeneration, satellite ... -
A 3-D Multiparametric Ultrasound Elasticity Imaging System for Targeted Prostate Biopsy Guidance
(2023)Prostate cancer is the most common cancer and second-leading cause of cancer death among men in the United States. Early and accurate diagnosis of prostate cancer remains challenging; following an abnormal rectal exam or ... -
A bidirectional switch to treat colonic dysmotility
(2023)Severe constipation can be life-threatening and disproportionately affects patients who may not benefit from conventional treatments. Sacral nerve stimulation (SNS) is an alternative to laxatives and pharmaceuticals, and ... -
A Comprehensive Framework for Adaptive Optics Scanning Light Ophthalmoscope Image Analysis
(2019)Diagnosis, prognosis, and treatment of many ocular and neurodegenerative diseases, including achromatopsia (ACHM), require the visualization of microscopic structures in the eye. The development of adaptive optics ophthalmic ... -
A Discrete Monolayer Cardiac Tissue Model for Tissue Preparation Specific Modeling
(2010)Engineered monolayers created by using microabrasion and micropatterning methods have provided a simplified in vitro system to study the effects of anisotropy and fiber direction on electrical propagation. Interpreting the ... -
A Framework for Dissecting and Applying Bacterial Antibiotic Responses
(2017)An essential property of microbial communities is the ability to survive a disturbance. This is readily observed in bacteria, which have developed the ability to survive every antibiotic treatment at an alarming rate, considering ... -
A mechanistic understanding of the postantibiotic effect and treatment strategies
(2017)Although antibiotics have proven to be one of the great achievements of modern medicine, their efficacy has dramatically decreased over the past several decades. This is due, in part, to the rapid pace of natural bacterial ... -
A Model of Lung Tumor Angiogenesis in a Biomimetic Poly(ethylene glycol)-based Hydrogel System
(2016)Tumor angiogenesis is critical to tumor growth and metastasis, yet much is unknown about the role vascular cells play in the tumor microenvironment. A major outstanding challenge associated with studying tumor angiogenesis ... -
A multilevel high-throughput sequencing approach for identifying microbial community interactions and informing precision microbiome engineering
(2023)A multilevel high-throughput sequencing approach for identifying microbial community interactions and informing precision microbiome engineering -
A Multiplexed, Multi-scale Optical Imaging Platform to Quantify Tumor Metabolic Heterogeneity
(2023)The American Cancer Society reported an estimated 300,000 new cases of breast cancer and 44,000 new breast-cancer related deaths in 2022 in the United States alone. With each new successfully treated primary tumor, there ... -
A Novel Immunoassay Platform Enabled by Non-fouling Poly(OEGMA) Surfaces
(2014)The primary barriers to multiplexed point of care immunoassays are: (1) cost; (2) response time; and (3) sample handling. Described here is a self-contained, multiplexed immunoassay platform for point of care detection that ... -
A Novel Vascular Graft Diagnostic and Reversible Aptamers for the Purification of Therapeutic Cells
(2017)Creation of novel tools for biomedical applications is critical for the improvement of patient diagnostics and therapeutics. Two particularly important needs lie in (1) improved in vitro testing and increased performance ... -
A Point-of-Care Immunoassay for Ultra-Sensitive Detection of Ebolavirus
(2020)Laboratory enabled disease diagnosis is one of the cornerstones in patient care and greatly relies in immunological techniques to detect pathogens and quantify biomarkers related to a myriad of clinical conditions. ... -
A Point-Of-Care Immunoassay Platform for Measuring Antibody Avidity
(2021)Serological testing—detection of antibodies—plays a key role in the diagnosis, management, and surveillance of infectious diseases. Serological assays can detect both active and past infections which is essential in understanding ... -
A Stem Cell-Based Strategy for Modeling Human Kidney Disease and Discovering Novel Therapeutics
(2022)Chronic kidney disease (CKD) is a degenerative disorder that affects millions of people worldwide and there are no targeted therapeutics. Given the global burden and increasing prevalence of CKD, the kidneys represent an ... -
A sublingual vaccine strategy based on tablet delivery of molecular assemblies
(2019)Vaccines have been a revolutionary intervention for infectious diseases over the past many decades. However, over 2 million people continue to die every year of vaccine-preventable causes, especially in low-resource areas. ... -
A Synthetic-biology Approach to Understanding Bacterial Programmed Death and Implications for Antibiotic Treatment
(2013)Programmed death is often associated with a bacterial stress response. This behavior appears paradoxical, as it offers no benefit to the individual. This paradox can be explained if the death is `altruistic': the sacrifice ... -
A Tissue-Engineered Blood Vessel Model for Vascular Aging
(2021)Clinical studies have identified strong correlations between aging and the development of atherosclerosis. In particular, endothelial cell senescence is implicated in age-related changes in vasoreactivity. Oxidative stress ... -
A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
(2015)The ability of tissue engineered constructs to replace diseased or damaged organs is limited without the incorporation of a functional vascular system. To design microvasculature that recapitulates the vascular niche functions ...
