Browsing by Department "Cell Biology"
Now showing items 1-20 of 64
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A Clonal Analysis of Zebrafish Heart Morphogenesis and Regeneration
(2014)As vertebrate embryos grow and develop into adults, their organs must acquire mass and mature tissue architecture to maintain proper homeostasis. While juvenile growth encompasses a significant portion of life, relatively ... -
A Genomic and Structural Study of FtsZ Function for Bacterial Cell Division
(2013)The tubulin homolog FtsZ provides the cytoskeletal framework for bacterial cell division. FtsZ is an essential protein for bacterial cell division, and is the only protein necessary for Z-ring assembly and constriction force ... -
A Systems Level Analysis of Temperature-Dependent Sex Determination in the Red-Eared Slider Turtle Trachemys Scripta Elegans.
(2016)Sex determination is a critical biological process for all sexually reproducing animals. Despite its significance, evolution has provided a vast array of mechanisms by which sexual phenotype is determined and elaborated ... -
Bioinformatics and Molecular Approaches for the Construction of Biological Artificial Cartilage
(2018)Osteoarthritis (OA) is one of the leading causes of disability in the United States, afflicting over 27 million Americans and imposing an economic burden of more than $128 billion each year (1, 2). OA is characterized by ... -
Cell Lineage Specification during Mouse Embryonic Gonad Development
(2017)The mouse embryonic gonad provides an outstanding model to study the complex mechanisms involved in cell fate specification and maintenance. At the bipotential stage, both XX and XY gonads are capable of becoming testes ... -
Cellular and Molecular Mechanisms of Cardiac Chamber Maturation in Zebrafish
(2018)The formation of the heart is a critical part of development that, if defective, can lead to congenital malformations incompatible with life. An improved understanding of the cellular and molecular processes that build the ... -
Cellular Mechanisms Regulating Single Lumen Formation in the Zebrafish Gut
(2014)The formation of a single lumen during tubulogenesis is crucial for the development and function of many organs. Although 3D cell culture models have identified molecular mechanisms controlling lumen formation in vitro, ... -
Characterization of the Actin Nucleator Cordon-bleu in Zebrafish
(2010)The means by which cells, tissues, and organisms undergo morphogenesis are variable and highly regulated, and the mechanisms that govern cellular changes in response to signaling cues are poorly understood. This study seeks ... -
Clonal Analysis of the Zebrafish Fin Regeneration Blastema
(2016)Regeneration is a remarkable feat of developmental regrowth and patterning. The blastema is a mass of progenitor cells that enables complete regeneration of amputated salamander limbs or fish fins. Despite years of study, ... -
Cryptococcus Neoformans Interactions with Surfactant Proteins: Implications for Innate Pulmonary Immunity
(2009)Concurrent with the global escalation of the AIDS pandemic, cryptococcal infections are increasing and are of significant medical importance. Although improvements in antifungal therapy have advanced the treatment ... -
Cytoskeletal Dynamics and the Temporal Control of Yeast Morphogenesis
(2012)The cells of the budding yeast Saccharomyces cerevisiae undergo a robust morphological cycle, involving reorganization of the actin cytoskeleton, septin ring formation, and polarized growth. These events are crucial to ... -
Decoding the Function of Ankyrin-B in Organelle Transport
(2016)Organelle transport in eukaryotic cells is regulated by a precisely coordinated activity of phosphoinositide lipids, small GTPases, and molecular motors. Despite the extensive study of functional activities of individual ... -
Development of a High-Throughput Human iPSC Chondrogenesis Platform and Applications for Arthritis Disease Modeling
(2019)The differentiation of human induced pluripotent stem cells (hiPSCs) to prescribed cell fates enables the engineering of patient-specific tissue types, such as hyaline cartilage, for applications in regenerative medicine, ... -
Extracellular Hsp90 is Actively Trafficked and Internalized in Breast Cancer Cells
(2016)Despite its ubiquitous abundance, Hsp90 inhibitors have shown promise in anti-cancer clinical trials, suggesting that Hsp90 inhibitors selectively target tumor cells while exhibiting minimal effects in normal cells. Extracellular ... -
Fibroblasts as a Window into the Cell Biology of Ankyrin -B and -G
(2011)The ankyrin family of proteins form specialized membrane domains in various cell types, including neurons and cardiomyocytes but little is known about how this process occurs. The majority of ankyrins localize to the plasma ... -
Formation and Function of Noncentrosomal Microtubule Arrays in Mammalian Epithelia
(2017)Microtubules play numerous roles in diverse cellular processes, including cell migration, intracellular trafficking, and chromosome segregation during cell division. Decades of research have defined many of the biochemical ... -
FtsZ Protofilament Curvature is the Opposite of Tubulin Rings
(2016)Bacterial tubulin homolog FtsZ assembles straight protofilaments (pfs) that form the scaffold of the cytokinetic Z ring. These pfs can adopt a curved conformation forming a miniring or spiral tube 24 nm in diameter. Tubulin ... -
Function of the Mouse PIWI Proteins and Biogenesis of Their piRNAs in the Male Germline
(2009)PIWI proteins belong to an evolutionary conserved protein family as the sister sub-family of ARGONAUTE (AGO) proteins. While AGO proteins are functionally well-characterized and shown to mediate small-RNA guided gene regulation, ... -
Functional Analysis of Ion Selectivity and Permeation Mechanisms of the C. elegans TRPV Channel OSM-9
(2011)For all organisms, the ability to sense and react to noxious environments is fundamental to their survival. For multi-celled organisms this process generally involves a nervous system and an extensive network of ... -
Functional Analysis of the Cordon-bleu Protein in Mouse
(2009)The actin cytoskeleton is a fundamental component of the cell and is involved in many processes, including cell division, cell migration, vesicle trafficking and cell polarity. The actin cytoskeleton has a very important ...
