Browsing by Department "DKU - Medical Physics Master of Science Program"
Now showing items 1-15 of 15
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A novel technique to irradiate surgical scars using dynamic electron arc radiotherapy
(2017)Purpose: The usage of conformal electron beam therapy techniques in treating superficial tumors on uneven surfaces has often lead to undesired outcomes such as non-uniform dose inside the target and a wide penumbra at boundary ... -
An Investigation in Quantitative Accuracy in Preablation I-131 Scans: 7-pinhole system compared with single-pinhole system.
(2018)Purpose: Early detection and prevention of differentiated thyroid cancer using thyroidectomy and ablation therapy can reduce disease persistence and recurrence. A preablation I-131 scan performed between the thyroidectomy ... -
An Investigation of Machine Learning Methods for Delta-radiomic Feature Analysis
(2018)Background: Radiomics is a process of converting medical images into high-dimensional quantitative features and the subsequent mining these features for providing decision support. It is conducted as a potential noninvasive, ... -
An Investigation of MR Sequences for Partial Volume Correction in PET Image Reconstruction
(2019)Brain Positron emission tomography (PET) has been widely employed for the clinic diagnosis of Alzheimer's disease (AD). Studies have shown that PET imaging is helpful in differentiating healthy elderly individuals, mild ... -
Automatic Pulmonary Nodule Detection and Localization from Biplanar Chest Radiographs Using Convolutional Neural Network
(2019)Chest x-ray (CXR) is the most common examination in pulmonary nodule detection and an automatic nodule detection algorithm is desirable. Currently, convolutional neural network (CNN) is widely applied in CXR. However, there ... -
Cone Beam Computed Tomography Image Quality Augmentation using Novel Deep Learning Networks
(2019)Purpose: Cone beam computed tomography (CBCT) plays an important role in image guidance for interventional radiology and radiation therapy by providing 3D volumetric images of the patient. However, CBCT suffers from relatively ... -
Development and Evaluation of a Perpendicular Frame-by-frame Patient-specific QA Method for Large VMAT Fields Using the TrueBeam Electronic Portal Imaging System
(2019)Background: The verification of VMAT delivery accuracy is widely performed with measurement-based QA methods and gamma index test evaluation. Having the gantry speed as an element of modulation requires that VMAT QA methods ... -
Effect of Lower-energy Source on the Tumor Representation in Neutron Stimulated Emission Computed Tomography: An Evaluation Study
(2017)Proposed is an investigation into the effect of lower-energy source on the tumor representation of an image acquired by a neutron-based spectroscopic imaging modality, Neutron Stimulated Emission Computed Tomography (NSECT).The ... -
Effect of Radiation and Immune Checkpoint Blockade (ICB) on Tumor Metastasis
(2017)Background: PD-L1 (Programmed Death Ligand 1) is an immune checkpoint molecule that is commonly expressed on the surface of cancer cells. When it interacts with its receptor – the PD-1 molecule, which is commonly expressed ... -
Evaluation of the Total Body Irradiation Treatment Planning Using Eclipse
(2019)Purpose: Total Body Irradiation (TBI) is typically performed at extended source-to-skin distance (SSD), and the treatment planning is done by simple point dose calculation based on measurement data. The goal of this study ... -
Improved Pre-clinical Radiation Treatment Techniques for a Novel Mouse Model of Head-and-neck Cancer
(2019)Mice are the predominant animal model used in radiation therapy research for investigating radiobiological kinetics and evaluating new therapeutics to achieve a higher therapeutic ratio in the clinic. A novel carcinogen-induced ... -
Investigating the Dosimetry Potential of the NIPAM Polymer Gel
(2019)Purpose: The aim of this work is to assess the potential of applying NIPAM polymer gel produced at Duke for CT and CBCT on board imaging for radiation therapy. This is after initial progress has been made in establishing ... -
Optimization of a limited-angle intrafraction verification (LIVE) system for target localization in radiation therapy of lung cancer
(2017)Purpose: A novel limited-angle intrafraction verification (LIVE) system has been developed recently for fast 4D intrafraction target verification in lung SBRT treatments. LIVE acquires orthogonal limited angle kV and MV ... -
Probability-Driven K-Space Based Multi-Cycle 4D-MRI Reconstruction
(2017)Purpose: Current 4D-MRI techniques are prone to motion artifacts caused by irregular breathing. This study aims to develop and evaluate a novel, motion-robust multi-cycle 4D-MRI technique to overcome this deficiency.Mate... -
Validating the Use of Boron Nanoparticles to Quantify Tumor Oxygen Tension in Irradiated Breast Tumors
(2019)Although hypoxia in tumors has long been identified as a key contributor to poor patient outcome, clinical solutions to lessen its deleterious effects have not been forthcoming. One reason is that there have been few means ...
