Browsing by Department "Genetics and Genomics"
Now showing items 1-20 of 177
-
A Genome-Wide RNAi Screen Identifies CDC-42 and GDI-1 as In Vivo Regulators of Invadopodia
(2015)Basement membrane (BM) is a sheet-like extracellular matrix that underlies most tissues and acts as a barrier to invading cells. Many cell types, including immune cells, cells migrating during development and morphogenesis, ... -
A Genomic Definition of Centromeres in Complex Genomes
(2011)Centromeres, or sites of chromosomal spindle attachment during mitosis and meiosis, are non-randomly distributed in complex genomes and are largely associated with expansive, near-identical satellite DNA arrays. While the ... -
A Novel Mechanism for Human Papillomavirus Mediated Tumorigenesis: Examining a Role for HPV E6 Protein in CYLD Mediated NF-kappaB Activation
(2009)Human papillomavirus (HPV) infection of mucosal epithelium by `high-risk' HPV types has a prominent role in the development of anogenital intraepithelial neoplasias and carcinomas. Human epithelial cells transformed with ... -
A systems-level view of mammalian sex determination.
(2010)Pathologies of sexual development are common in humans and reflect the precarious processes of sex determination and sexual differentiation. The gonad forms as a bipotential organ, and recent results from the Capel lab revealed ... -
A Tale of Two Proteins: Insights into the Haemophilus influenzae Hap and Hia Autotransporters
(2011)Nontypeable Haemophilus influenzae (NTHi) is a common commensal in the human nasopharynx that can cause localized respiratory tract diseases such as otitis media, bronchitis, and pneumonia. NTHi adheres to respiratory epithelial ... -
AAV Delivery of CFH Constructs for Complement Regulation in the Murine Eye
(2022)Age-related macular degeneration (AMD), a major cause of irreversible vision loss in elderly populations, has been associated genetically with the complement system, and especially with complement factor H (CFH). However, ... -
Acute and Intergenerational Nutrient Responses in Caenorhabditis elegans
(2017)Nearly all animals live in environments with fluctuations in nutrient availability. The ability to sense and respond to these changes is essential for survival. Nutrition impacts physiology immediately, but can also have ... -
An evolutionary genomics approach towards understanding Plasmodium vivax in central Africa
(2022)Increased attention has recently been placed on understanding the natural variation of the malaria parasite Plasmodium vivax across the globe, as in 2020 alone, P. vivax caused an estimated 4.5 million malaria cases and ... -
Analysis of the Drosophila Sugar Receptor Genes
(2009)Gustation, also known as taste perception, is critical for the survival of most animal species. The fruit fly Drosophila melanogaster employs 68 different gustatory receptors (GRs) for the detection of sugars, bitter or ... -
Ancestry-based Methods for Characterizing the Evolutionary History of Admixed Populations
(2022)Admixture occurs when previously isolated populations come together to form a new population with genetic ancestry from those sources. Admixture is ubiquitous across the tree of life, including humans, and is often associated ... -
Aneuploidy Tolerance in a Polyploid Organ
(2016)Endopolyploid cells (hereafter - polyploid cells), which contain whole genome duplications in an otherwise diploid organism, play vital roles in development and physiology of diverse organs such as our heart and liver. Polyploidy ... -
Basement Membrane Dynamics During Anchor Cell Invasion
(2015)Basement membranes are a dense, sheet-like form of extracellular matrix that underlie epithelia and endothelia, and surround muscle, fat and Schwann cells. Basement membranes separate tissues and protect them from mechanical ... -
Causes and consequences of microbial symbioses; insights from comparative genomics of plant associated bacterial-fungal interactions
(2017)Symbioses have shaped our modern world, providing for the air we breathe; for the plant and animal diversity we celebrate; and for the functioning of ecosystems from the tops of mountains to the ocean floor. Here I study ... -
Cell Fate Specification and the Regulation of RNA-dependent DNA Methylation in the Arabidopsis Root Meristem
(2016)The Arabidopsis root apical meristem (RAM) is a complex tissue capable of generating all the cell types that ultimately make up the root. The work presented in this thesis takes advantage of the versatility of high-throughput ... -
Cell Polarity Establishment in the Budding Yeast Saccharomyces Cerevisiae
(2009)Establishing an axis of cell polarity is central to cell motility, tissue morphogenesis, and cell proliferation. A highly conserved group of polarity regulators is responsible for organizing a wide variety of polarized ... -
Cerebral Cavernous Malformations: From Two-Hit Mechanism to Developing a Targeted Therapy
(2013)Cerebral cavernous malformations (CCMs) are multicavernous vascular lesions affecting the central nervous system. Affected individuals have a lifetime risk of recurrent headaches, focal neurological deficits, seizures, ... -
Characterization of Drosophila Ctr1a: New Roles for Ctr1 Proteins and Copper in Physiology and Cell Signaling Pathways
(2008-10-21)Copper is an essential trace element required by all aerobic organisms as a co-factor for enzymes involved in normal growth, development and physiology. Ctr1 proteins are members of a highly conserved family of copper importers ... -
Characterizing Genetic Drivers of Lymphoma through High-Throughput Sequencing
(2016)The advent of next-generation sequencing, now nearing a decade in age, has enabled, among other capabilities, measurement of genome-wide sequence features at unprecedented scale and resolution. In this dissertation, I describe ... -
Characterizing the Relationship Between Cell-Cycle Progression and a Transcriptional Oscillator
(2013)The cell division cycle is the process in which the entirety of a cell's contents is duplicated completely and then equally segregated into two identical daughter cells. The order of the steps in the cell cycle must be followed ... -
Chemical and Genetic Modulation of the Host Immune Response to Mycobacterial Infection
(2018)Mycobacterium tuberculosis (Mtb) is the causative agent of the disease tuberculosis, which kills more people worldwide than any other infectious disease. In 2017, nearly 2 million people died of tuberculosis. Despite the ...
