Browsing by Department "Molecular Genetics and Microbiology"
Now showing items 1-20 of 100
-
Achieving Cell-Specific Delivery of Multiple Oligonucleotide Therapeutics with Aptamer Chimeras
(2012)Current standard cancer treatments such as chemotherapeutics, and radiation therapy are nearly as likely to kill the patient as cure the cancer. Therapies that have such a narrow window of efficacy are necessary for the ... -
Activation and Subversion of MDA5-Dependent Immune Responses by the Engineered Oncolytic Poliovirus PVSRIPO
(2018)Cancer-specific cytopathogenicity of oncolytic viruses is often defined by viralsensitivity to innate antiviral immune responses, e.g. type I Interferons (IFNs), limitingcytotoxicity to cells lacking these responses. However, ... -
Analysis of the Interaction between Viruses, Mirnas and the Rnai Pathway
(2008-04-03)The microRNA (miRNA) and RNA interference (RNAi) pathways have recently emerged as an important aspect of virus-host cell interaction. This interaction can occur in several different ways and may favor either the virus or ... -
Antineoplastic Cytotoxicity and Immune Adjuvancy of a Recombinant Oncolytic Poliovirus
(2016)Our group has pioneered the development of a live-attenuated poliovirus, called PVSRIPO, for the purpose of targeting cancer. Despite clinical progress, the cancer selective cytotoxicity and immunotherapeutic potential of ... -
Cell Wall Lipids Promoting Host Angiogenesis During Mycobacterial Infection
(2018)Mycobacterial infection leads to the formation of characteristic immune cell aggregates called granulomas. In humans and animal models, tuberculous granuloma formation is accompanied by dramatic remodeling of host vasculature ... -
Cellular Responses to Lactic Acidosis in Human Cancers
(2010)The physiology of the tumor microenvironment is characterized by lower oxygen (hypoxia), higher lactate, extracellular acidosis and glucose starvation. We examined the global, transcriptional cellular responses to each of ... -
Cha-Cha-Cha: Variable Adhesive Activity of the <italic>Haemophilus</Italic> Cryptic Genospecies Trimeric Autotransporter Cha
(2009)Disease caused by the Gram-negative <italic>Haemophilus</italic> cryptic genospecies begins with colonization of the maternal genital or neonatal respiratory tract. The primary goal of this work was to identify and characterize ... -
Characterization of Host Factors and Anti-viral Compounds for Diverse Mosquito-borne Flaviviruses
(2016)Our ability to convert basic knowledge into robust anti-viral therapeutics requires discovery of novel host-virus interactions as well as an informed anti-viral discovery pipeline. We used a genome-scale RNAi-based screen ... -
Characterizing Stress-Induced Outer Membrane Vesicle Production in Pseudomonas aeruginosa
(2013)As an opportunistic Gram-negative pathogen, Pseudomonas aeruginosa must be able to adapt to changes and survive stressors in its environment during the course of infection. To aid survival in the hostile host environment, ... -
Chlamydia Subversion of Host Lipid Transport: Interactions with Cytoplasmic Lipid Droplets
(2009)The <italic>Chlamydiaceae</italic> are Gram-negative, obligate intracellular bacteria that are significant pathogens of humans and animals. Intracellularly, the bacteria reside in a membrane-bound vacuole, called the inclusion, ... -
Chromatin Accessibility Dynamics Underlying Development and Disease
(2015)Despite a largely static DNA sequence, our genomes are incredibly malleable. Comparative studies of chromatin features between different cell types, tissues, and species have revealed tremendous differences in how the genome ... -
Cooption of Innate Immune Cells in Promoting and Combating Infections
(2018)The key components of innate immune defense to pathogens are various migratory as well as tissue resident innate immune cells, however, their interactions with pathogens as well as their immune-orchestrating roles are often ... -
Defining the Role of Antibodies in Protection Against Cytomegalovirus Acquisition and Congenital Disease for Rational Vaccine Design
(2018)Human cytomegalovirus (HCMV) is the most common cause of congenital infection worldwide, impacting 1 in 150 live-born infants. Children afflicted by congenital HCMV frequently suffer from lifelong, debilitating neurologic ... -
Defining the Role of Host Cell Chromatin Traps in Chlamydia trachomatis Pathogenesis
(2016)Chlamydia trachomatis (CT) is the most common bacterial agent of sexually transmitted infection and can cause damaging inflammation of the female reproductive tract. As an obligate intracellular pathogen, CT must exit exhausted ... -
Dengue Virus Host Factors
(2009)Dengue fever and dengue hemorrhagic fever are estimated to afflict 50-100 million people annually and are caused by one of the four serotypes of dengue virus. Dengue virus is carried and transmitted to humans by mosquitoes ... -
DNA Damage Response Suppresses Epstein-Barr Virus-Driven Proliferation of Primary Human B Cells
(2012)The interaction of human tumor viruses with host growth suppressive pathways is a fine balance between controlled latent infection and virus-induced oncogenesis. This dissertation elucidates how Epstein-Barr virus interacts ... -
Drug Development in Dengue Virus and Molecular Epidemiology of Malaria in Western Kenya
(2017)Dengue viruses (DENV) and other mosquito-borne flaviviruses are rapidly emerging human pathogens that threaten nearly half of the world’s population. There is currently no effective vaccine or antiviral therapeutics for ... -
EBV BART MicroRNAs Target Pro-apoptotic and Anti-Wnt Signaling Genes to Promote Cell Survival and Proliferation
(2015)Epstein-Barr virus (EBV) is a ubiquitous human gamma-herpesvirus which chronically infects >95% of the global population, and can give rise to a number of malignancies in B cells and epithelial cells. In EBV latently infected ... -
Elucidating Plasmodium Liver Stage Biology Through Transcriptomic Approaches
(2018)Malaria is one of the leading causes of mortality attributed to infectious diseases worldwide. Every year, hundreds of thousands of children succumb to the disease and hundreds of millions more suffer the characteristic ... -
Envelope-specific IgG Responses in HIV-infected Women
(2018)A better understanding of 1) maternal HIV Envelope (Env)-specific IgG responses that are partially protective against vertical HIV transmission, and 2) factors that mediate the transplacental transfer of maternal protective ...
