Browsing by Subject "ATM"
Now showing items 1-4 of 4
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Dissecting Tumor Response to Radiation Therapy Using Genetically Engineered Mouse Models
(2015)Approximately 50% of all patients with cancer receive radiation therapy at some point during the course of their illness. Despite advances in radiation delivery and treatment planning, normal tissue toxicity often limits ... -
Post-translational Regulation of RPA32, ATM and Rad17 Controls the DNA Damage Response
(2009)The eukaryotic genome integrity is safeguarded by the DNA damage response, which is composed of a network of signal transduction pathways that upon genotoxic stresses, arrest cell cycle progression, motivate repair processes, ... -
Tel1p and Mec1p Regulate Chromosome Segregation and Chromosome Rearrangements in <italic>Saccharomyces cerevisiae</italic>
(2010)Cancer cells often have elevated frequencies of chromosomal aberrations, and it is likely that loss of genome stability is one driving force behind tumorigenesis. Deficiencies in DNA replication, DNA repair, or cell cycle ... -
Using Genetically Engineered Mouse Models to Dissect the Critical Cellular Target of Radiation Therapy
(2018)Approximately half of all cancer patients will receive radiation as part of their treatment regimen in either a palliative or curative setting. Conventionally, radiation therapy has been administered to patients in small ...
