Now showing items 1-6 of 6

    • Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. 

      Freeman, K; Lerman, I; Kranias, EG; Bohlmeyer, T; Bristow, MR; Lefkowitz, RJ; Iaccarino, G; ... (9 authors) (J Clin Invest, 2001-04)
      The medical treatment of chronic heart failure has undergone a dramatic transition in the past decade. Short-term approaches for altering hemodynamics have given way to long-term, reparative strategies, including beta-adrenergic ...
    • Developmental mechanism of the periodic membrane skeleton in axons. 

      Zhong, Guisheng; He, Jiang; Zhou, Ruobo; Lorenzo, Damaris; Babcock, Hazen P; Bennett, Vann; Zhuang, Xiaowei (Elife, 2014-12-23)
      Actin, spectrin, and associated molecules form a periodic sub-membrane lattice structure in axons. How this membrane skeleton is developed and why it preferentially forms in axons are unknown. Here, we studied the developmental ...
    • Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions. 

      Wu, Shenping; Liu, Jun; Reedy, Mary C; Tregear, Richard T; Winkler, Hanspeter; Franzini-Armstrong, Clara; Sasaki, Hiroyuki; ... (11 authors) (PLoS One, 2010-09-09)
      BACKGROUND: Isometric muscle contraction, where force is generated without muscle shortening, is a molecular traffic jam in which the number of actin-attached motors is maximized and all states of motor action are trapped ...
    • Regulation of spine structural plasticity by Arc/Arg3.1. 

      Newpher, Thomas M; Harris, Scott; Pringle, Jasmine; Hamilton, Colleen; Soderling, Scott (Seminars in cell & developmental biology, 2018-05)
      Dendritic spines are actin-rich, postsynaptic protrusions that contact presynaptic terminals to form excitatory chemical synapses. These synaptic contacts are widely believed to be the sites of memory formation and information ...
    • Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis. 

      Chi, Richard J; Torres, Onaidy T; Segarra, Verónica A; Lansley, Tanya; Chang, Ji Suk; Newpher, Thomas M; Lemmon, Sandra K (J Cell Sci, 2012-10-15)
      Phosphorylation regulates assembly and disassembly of proteins during endocytosis. In yeast, Prk1 and Ark1 phosphorylate factors after vesicle internalization leading to coat disassembly. Scd5, a protein phosphatase-1 ...
    • UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity. 

      Wang, Zheng; Linden, Lara M; Naegeli, Kaleb M; Ziel, Joshua W; Chi, Qiuyi; Hagedorn, Elliott J; Savage, Natasha S; ... (8 authors) (J Cell Biol, 2014-09-01)
      The receptor deleted in colorectal cancer (DCC) directs dynamic polarizing activities in animals toward its extracellular ligand netrin. How DCC polarizes toward netrin is poorly understood. By performing live-cell imaging ...