Now showing items 1-20 of 34

    • Anatomical identification of extracellularly recorded cells in large-scale multielectrode recordings. 

      Li, Peter H; Gauthier, Jeffrey L; Schiff, Max; Sher, Alexander; Ahn, Daniel; Field, Greg D; Greschner, Martin; ... (10 authors) (J Neurosci, 2015-03-18)
      This study combines for the first time two major approaches to understanding the function and structure of neural circuits: large-scale multielectrode recordings, and confocal imaging of labeled neurons. To achieve this ...
    • Auditory signals evolve from hybrid- to eye-centered coordinates in the primate superior colliculus. 

      Lee, Jungah; Groh, Jennifer M (Journal of neurophysiology, 2012-07)
      Visual and auditory spatial signals initially arise in different reference frames. It has been postulated that auditory signals are translated from a head-centered to an eye-centered frame of reference compatible with the ...
    • Bistability and up/down state alternations in inhibition-dominated randomly connected networks of LIF neurons. 

      Tartaglia, Elisa M; Brunel, Nicolas (Scientific reports, 2017-09-20)
      Electrophysiological recordings in cortex in vivo have revealed a rich variety of dynamical regimes ranging from irregular asynchronous states to a diversity of synchronized states, depending on species, anesthesia, and ...
    • Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors. 

      Bouvier, Guy; Higgins, David; Spolidoro, Maria; Carrel, Damien; Mathieu, Benjamin; Léna, Clément; Dieudonné, Stéphane; ... (10 authors) (Cell reports, 2016-04)
      Numerous studies have shown that cerebellar function is related to the plasticity at the synapses between parallel fibers and Purkinje cells. How specific input patterns determine plasticity outcomes, as well as the biophysics ...
    • Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats. 

      Yu, Wan-Qing; Grzywacz, Norberto M; Lee, Eun-Jin; Field, Greg D (Journal of neurophysiology, 2017-07)
      We have determined the impact of rod death and cone reorganization on the spatiotemporal receptive fields (RFs) and spontaneous activity of distinct retinal ganglion cell (RGC) types. We compared RGC function between healthy ...
    • Cerebellar learning using perturbations. 

      Bouvier, Guy; Aljadeff, Johnatan; Clopath, Claudia; Bimbard, Célian; Ranft, Jonas; Blot, Antonin; Nadal, Jean-Pierre; ... (10 authors) (eLife, 2018-11-12)
      The cerebellum aids the learning of fast, coordinated movements. According to current consensus, erroneously active parallel fibre synapses are depressed by complex spikes signalling movement errors. However, this theory ...
    • Computational inference of neural information flow networks. 

      Smith, V Anne; Yu, Jing; Smulders, Tom V; Hartemink, Alexander J; Jarvis, Erich D (PLoS Comput Biol, 2006-11-24)
      Determining how information flows along anatomical brain pathways is a fundamental requirement for understanding how animals perceive their environments, learn, and behave. Attempts to reveal such neural information flow ...
    • Corollary discharge across the animal kingdom. 

      Crapse, Trinity B; Sommer, Marc A (Nat Rev Neurosci, 2008-08)
      Our movements can hinder our ability to sense the world. Movements can induce sensory input (for example, when you hit something) that is indistinguishable from the input that is caused by external agents (for example, when ...
    • Cortical dynamics during naturalistic sensory stimulations: experiments and models. 

      Mazzoni, Alberto; Brunel, Nicolas; Cavallari, Stefano; Logothetis, Nikos K; Panzeri, Stefano (Journal of physiology, Paris, 2011-01)
      We report the results of our experimental and theoretical investigations of the neural response dynamics in primary visual cortex (V1) during naturalistic visual stimulation. We recorded Local Field Potentials (LFPs) and ...
    • Drivers from the deep: the contribution of collicular input to thalamocortical processing. 

      Wurtz, Robert H; Sommer, Marc A; Cavanaugh, James (Prog Brain Res, 2005)
      A traditional view of the thalamus is that it is a relay station which receives sensory input and conveys this information to cortex. This sensory input determines most of the properties of first order thalamic neurons, ...
    • Effects of frequency-dependent membrane capacitance on neural excitability. 

      Howell, Bryan; Medina, Leonel E; Grill, Warren M (Journal of neural engineering, 2015-10)
      <h4>Objective</h4>Models of excitable cells consider the membrane specific capacitance as a ubiquitous and constant parameter. However, experimental measurements show that the membrane capacitance declines with increasing ...
    • Estimating network parameters from combined dynamics of firing rate and irregularity of single neurons. 

      Hamaguchi, Kosuke; Riehle, Alexa; Brunel, Nicolas (Journal of neurophysiology, 2011-01)
      High firing irregularity is a hallmark of cortical neurons in vivo, and modeling studies suggest a balance of excitation and inhibition is necessary to explain this high irregularity. Such a balance must be generated, at ...
    • From spiking neuron models to linear-nonlinear models. 

      Ostojic, Srdjan; Brunel, Nicolas (PLoS Comput Biol, 2011-01-20)
      Neurons transform time-varying inputs into action potentials emitted stochastically at a time dependent rate. The mapping from current input to output firing rate is often represented with the help of phenomenological models ...
    • Frontal eye field neurons assess visual stability across saccades. 

      Crapse, Trinity B; Sommer, Marc A (J Neurosci, 2012-02-22)
      The image on the retina may move because the eyes move, or because something in the visual scene moves. The brain is not fooled by this ambiguity. Even as we make saccades, we are able to detect whether visual objects remain ...
    • High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina. 

      Field, Greg D; Greschner, Martin; Gauthier, Jeffrey L; Rangel, Carolina; Shlens, Jonathon; Sher, Alexander; Marshak, David W; ... (9 authors) (Nat Neurosci, 2009-09)
      Small bistratified cells (SBCs) in the primate retina carry a major blue-yellow opponent signal to the brain. We found that SBCs also carry signals from rod photoreceptors, with the same sign as S cone input. SBCs exhibited ...
    • Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues. 

      Christoforou, Nicolas; Liau, Brian; Chakraborty, Syandan; Chellapan, Malathi; Bursac, Nenad; Leong, Kam W (PLoS One, 2013)
      The mammalian heart has little capacity to regenerate, and following injury the myocardium is replaced by non-contractile scar tissue. Consequently, increased wall stress and workload on the remaining myocardium leads to ...
    • Inferring learning rules from distributions of firing rates in cortical neurons. 

      Lim, Sukbin; McKee, Jillian L; Woloszyn, Luke; Amit, Yali; Freedman, David J; Sheinberg, David L; Brunel, Nicolas (Nat Neurosci, 2015-12)
      Information about external stimuli is thought to be stored in cortical circuits through experience-dependent modifications of synaptic connectivity. These modifications of network connectivity should lead to changes in neuronal ...
    • Microcircuits for attention. 

      Sommer, Marc A (Neuron, 2007-07-05)
      Researchers who study the neuronal basis of cognition face a paradox. If they extract the brain, its cognitive functions cannot be assessed. On the other hand, the brain's microcircuits are difficult to study in the intact ...
    • Modulation of network excitability by persistent activity: how working memory affects the response to incoming stimuli. 

      Tartaglia, Elisa M; Brunel, Nicolas; Mongillo, Gianluigi (PLoS Comput Biol, 2015-02)
      Persistent activity and match effects are widely regarded as neuronal correlates of short-term storage and manipulation of information, with the first serving active maintenance and the latter supporting the comparison between ...
    • Neuronal morphology generates high-frequency firing resonance. 

      Ostojic, Srdjan; Szapiro, Germán; Schwartz, Eric; Barbour, Boris; Brunel, Nicolas; Hakim, Vincent (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015-05)
      The attenuation of neuronal voltage responses to high-frequency current inputs by the membrane capacitance is believed to limit single-cell bandwidth. However, neuronal populations subject to stochastic fluctuations can ...