Now showing items 1-20 of 21

    • Anatomical identification of extracellularly recorded cells in large-scale multielectrode recordings. 

      Li, Peter H; Gauthier, Jeffrey L; Schiff, Max; Sher, Alexander; Ahn, Daniel; Field, Greg D; Greschner, Martin; ... (10 authors) (J Neurosci, 2015-03-18)
      This study combines for the first time two major approaches to understanding the function and structure of neural circuits: large-scale multielectrode recordings, and confocal imaging of labeled neurons. To achieve this ...
    • Auditory signals evolve from hybrid- to eye-centered coordinates in the primate superior colliculus. 

      Lee, Jungah; Groh, Jennifer M (Journal of neurophysiology, 2012-07)
      Visual and auditory spatial signals initially arise in different reference frames. It has been postulated that auditory signals are translated from a head-centered to an eye-centered frame of reference compatible with the ...
    • Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats. 

      Yu, Wan-Qing; Grzywacz, Norberto M; Lee, Eun-Jin; Field, Greg D (Journal of neurophysiology, 2017-07)
      We have determined the impact of rod death and cone reorganization on the spatiotemporal receptive fields (RFs) and spontaneous activity of distinct retinal ganglion cell (RGC) types. We compared RGC function between healthy ...
    • Computational inference of neural information flow networks. 

      Smith, V Anne; Yu, Jing; Smulders, Tom V; Hartemink, Alexander J; Jarvis, Erich D (PLoS Comput Biol, 2006-11-24)
      Determining how information flows along anatomical brain pathways is a fundamental requirement for understanding how animals perceive their environments, learn, and behave. Attempts to reveal such neural information flow ...
    • Corollary discharge across the animal kingdom. 

      Crapse, Trinity B; Sommer, Marc A (Nat Rev Neurosci, 2008-08)
      Our movements can hinder our ability to sense the world. Movements can induce sensory input (for example, when you hit something) that is indistinguishable from the input that is caused by external agents (for example, when ...
    • Drivers from the deep: the contribution of collicular input to thalamocortical processing. 

      Wurtz, Robert H; Sommer, Marc A; Cavanaugh, James (Prog Brain Res, 2005)
      A traditional view of the thalamus is that it is a relay station which receives sensory input and conveys this information to cortex. This sensory input determines most of the properties of first order thalamic neurons, ...
    • From spiking neuron models to linear-nonlinear models. 

      Ostojic, Srdjan; Brunel, Nicolas (PLoS Comput Biol, 2011-01-20)
      Neurons transform time-varying inputs into action potentials emitted stochastically at a time dependent rate. The mapping from current input to output firing rate is often represented with the help of phenomenological models ...
    • Frontal eye field neurons assess visual stability across saccades. 

      Crapse, Trinity B; Sommer, Marc A (J Neurosci, 2012-02-22)
      The image on the retina may move because the eyes move, or because something in the visual scene moves. The brain is not fooled by this ambiguity. Even as we make saccades, we are able to detect whether visual objects remain ...
    • High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina. 

      Field, Greg D; Greschner, Martin; Gauthier, Jeffrey L; Rangel, Carolina; Shlens, Jonathon; Sher, Alexander; Marshak, David W; ... (9 authors) (Nat Neurosci, 2009-09)
      Small bistratified cells (SBCs) in the primate retina carry a major blue-yellow opponent signal to the brain. We found that SBCs also carry signals from rod photoreceptors, with the same sign as S cone input. SBCs exhibited ...
    • Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues. 

      Christoforou, Nicolas; Liau, Brian; Chakraborty, Syandan; Chellapan, Malathi; Bursac, Nenad; Leong, Kam W (PLoS One, 2013)
      The mammalian heart has little capacity to regenerate, and following injury the myocardium is replaced by non-contractile scar tissue. Consequently, increased wall stress and workload on the remaining myocardium leads to ...
    • Inferring learning rules from distributions of firing rates in cortical neurons. 

      Lim, Sukbin; McKee, Jillian L; Woloszyn, Luke; Amit, Yali; Freedman, David J; Sheinberg, David L; Brunel, Nicolas (Nat Neurosci, 2015-12)
      Information about external stimuli is thought to be stored in cortical circuits through experience-dependent modifications of synaptic connectivity. These modifications of network connectivity should lead to changes in neuronal ...
    • Microcircuits for attention. 

      Sommer, Marc A (Neuron, 2007-07-05)
      Researchers who study the neuronal basis of cognition face a paradox. If they extract the brain, its cognitive functions cannot be assessed. On the other hand, the brain's microcircuits are difficult to study in the intact ...
    • Modulation of network excitability by persistent activity: how working memory affects the response to incoming stimuli. 

      Tartaglia, Elisa M; Brunel, Nicolas; Mongillo, Gianluigi (PLoS Comput Biol, 2015-02)
      Persistent activity and match effects are widely regarded as neuronal correlates of short-term storage and manipulation of information, with the first serving active maintenance and the latter supporting the comparison between ...
    • Retinal representation of the elementary visual signal. 

      Li, Peter H; Field, Greg D; Greschner, Martin; Ahn, Daniel; Gunning, Deborah E; Mathieson, Keith; Sher, Alexander; ... (9 authors) (Neuron, 2014-01)
      The propagation of visual signals from individual cone photoreceptors through parallel neural circuits was examined in the primate retina. Targeted stimulation of individual cones was combined with simultaneous recording ...
    • Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates. 

      Mueller, Jerel K; Grigsby, Erinn M; Prevosto, Vincent; Petraglia, Frank W; Rao, Hrishikesh; Deng, Zhi-De; Peterchev, Angel V; ... (11 authors) (Nat Neurosci, 2014-08)
      Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report new methods for studying the influence of TMS ...
    • Single neurons may encode simultaneous stimuli by switching between activity patterns. 

      Caruso, Valeria C; Mohl, Jeff T; Glynn, Christopher; Lee, Jungah; Willett, Shawn M; Zaman, Azeem; Ebihara, Akinori F; ... (11 authors) (Nature communications, 2018-07-13)
      How the brain preserves information about multiple simultaneous items is poorly understood. We report that single neurons can represent multiple stimuli by interleaving signals across time. We record single units in an auditory ...
    • Spatial and temporal scales of neuronal correlation in visual area V4. 

      Smith, Matthew A; Sommer, Marc A (J Neurosci, 2013-03-20)
      The spiking activity of nearby cortical neurons is correlated on both short and long time scales. Understanding this shared variability in firing patterns is critical for appreciating the representation of sensory stimuli ...
    • Spike avalanches exhibit universal dynamics across the sleep-wake cycle. 

      Ribeiro, Tiago L; Copelli, Mauro; Caixeta, Fábio; Belchior, Hindiael; Chialvo, Dante R; Nicolelis, Miguel AL; Ribeiro, Sidarta (PLoS One, 2010-11-30)
      BACKGROUND: Scale-invariant neuronal avalanches have been observed in cell cultures and slices as well as anesthetized and awake brains, suggesting that the brain operates near criticality, i.e. within a narrow margin between ...
    • Storage of correlated patterns in standard and bistable Purkinje cell models. 

      Clopath, Claudia; Nadal, Jean-Pierre; Brunel, Nicolas (PLoS Comput Biol, 2012)
      The cerebellum has long been considered to undergo supervised learning, with climbing fibers acting as a 'teaching' or 'error' signal. Purkinje cells (PCs), the sole output of the cerebellar cortex, have been considered ...
    • The evolving capabilities of rhodopsin-based genetically encoded voltage indicators. 

      Gong, Yiyang (Curr Opin Chem Biol, 2015-08)
      Protein engineering over the past four years has made rhodopsin-based genetically encoded voltage indicators a leading candidate to achieve the task of reporting action potentials from a population of genetically targeted ...