Browsing by Subject "Aging"
Now showing items 1-20 of 136
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Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.
(Aging, 2020-12)<h4>Background</h4>Accelerated epigenetic age has been proposed as a biomarker of increased aging, which may indicate disruptions in cellular and organ system homeostasis and thus contribute to sensitivity to environmental ... -
Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice.
(Shock (Augusta, Ga.), 2021-11)<h4>Abstract</h4>After cardiac arrest (CA) and resuscitation, the unfolded protein response (UPR) is activated in various organs including the brain. However, the role of the UPR in CA outcome remains largely unknown. One ... -
Adult age differences in frontostriatal representation of prediction error but not reward outcome.
(Cogn Affect Behav Neurosci, 2014-06)Emerging evidence from decision neuroscience suggests that although younger and older adults show similar frontostriatal representations of reward magnitude, older adults often show deficits in feedback-driven reinforcement ... -
Adult age differences in functional connectivity during executive control.
(Neuroimage, 2010-08-15)Task switching requires executive control processes that undergo age-related decline. Previous neuroimaging studies have identified age-related differences in brain activation associated with global switching effects (dual-task ... -
Age Differences in Suggestibility Following Semantic Illusions: The Role of Prior Knowledge
(2014)In the face of declines in memory related to specific events, people maintain intact general knowledge into very old age. Older adults often use this knowledge to support their remembering. Semantic illusions involve situations ... -
Age mediation of frontoparietal activation during visual feature search.
(Neuroimage, 2014-11-15)Activation of frontal and parietal brain regions is associated with attentional control during visual search. We used fMRI to characterize age-related differences in frontoparietal activation in a highly efficient feature ... -
Age trajectories of physiological indices in relation to healthy life course.
(Mech Ageing Dev, 2011-03)We analysed relationship between the risk of onset of "unhealthy life" (defined as the onset of cancer, cardiovascular diseases, or diabetes) and longitudinal changes in body mass index, diastolic blood pressure, hematocrit, ... -
Age-related changes in the cellular composition and epithelial organization of the mouse trachea.
(PloS one, 2014-01)We report here senescent changes in the structure and organization of the mucociliary pseudostratified epithelium of the mouse trachea and main stem bronchi. We confirm previous reports of the gradual appearance of age-related, ... -
Age-related differences in resolving semantic and phonological competition during receptive language tasks.
(Neuropsychologia, 2016-12)Receptive language (e.g., reading) is largely preserved in the aging brain, and semantic processes in particular may continue to develop throughout the lifespan. We investigated the neural underpinnings of phonological and ... -
Age-related differences in the neural bases of phonological and semantic processes in the context of task-irrelevant information.
(Cognitive, affective & behavioral neuroscience, 2019-08)As we age we have increasing difficulty with phonological aspects of language production. Yet semantic processes are largely stable across the life span. This suggests a fundamental difference in the cognitive and potentially ... -
Age-related differences in the neural bases of phonological and semantic processes.
(Journal of cognitive neuroscience, 2014-12)Changes in language functions during normal aging are greater for phonological compared with semantic processes. To investigate the behavioral and neural basis for these age-related differences, we used fMRI to examine younger ... -
Age-related effects on the neural correlates of autobiographical memory retrieval.
(Neurobiol Aging, 2012-07)Older adults recall less episodically rich autobiographical memories (AM), however, the neural basis of this effect is not clear. Using functional MRI, we examined the effects of age during search and elaboration phases ... -
Age-related preservation of top-down control over distraction in visual search.
(Experimental aging research, 2010-07)Visual search studies have demonstrated that older adults can have preserved or even increased top-down control over distraction. However, the results are mixed as to the extent of this age-related preservation. The present ... -
Age-related slowing in the retrieval of information from long-term memory.
(Journal of gerontology, 1985-03)The present experiment investigated adult age differences in the retrieval of information from long-term memory. Each trial required a decision regarding the synonymy of two visually presented words. On the yes-response ... -
Aging and health--a systems biology perspective. Introduction.
(Interdiscip Top Gerontol, 2015) -
Aging in South Asia: Attitudes/Beliefs of Elders in Southern India and Long-Term Care of the Elderly in Southern Sri Lanka
(2013)Developing nations in Asia are posed to experience a significant increase in the population of older adults living in their respective societies. Over the coming decades, India, the second most populous country in the entire ... -
Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice.
(Journal of the American Heart Association, 2018-09)Background The mechanisms underlying worse outcome at advanced age after cardiac arrest ( CA ) and resuscitation are not well understood. Because protein homeostasis (proteostasis) is essential for cellular and organismal ... -
Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats.
(Brain Struct Funct, 2013-05)Rodent models of Huntington disease (HD) are valuable tools for investigating HD pathophysiology and evaluating new therapeutic approaches. Non-invasive characterization of HD-related phenotype changes is important for monitoring ... -
An Induced Pluripotent Stem Cell-derived Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome for Disease Modeling and Drug Testing
(2018)Hutchison-Gilford Progeria Syndrome (HGPS) is a rare, accelerated aging disorder caused by nuclear accumulation of progerin, an altered form of the Lamin A gene. The primary causes of death are stroke and cardiovascular ... -
Application of the Stability of Proteins from Rates of Oxidation Technique to the Analysis of Mouse Models of Aging and Parkinson's Disease
(2017)Recently, several mass spectrometry-based proteomics techniques have been developed for the large-scale analysis of thermodynamic measurements of protein stability. This has created the possibility of characterizing disease ...
