Browsing by Subject "Aneuploidy"
Now showing items 1-3 of 3
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Expression in aneuploid Drosophila S2 cells.
(PLoS Biol, 2010-02-23)Extensive departures from balanced gene dose in aneuploids are highly deleterious. However, we know very little about the relationship between gene copy number and expression in aneuploid cells. We determined copy number ... -
Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers.
(PLoS Comput Biol, 2010-09-02)Tumor microenvironmental stresses, such as hypoxia and lactic acidosis, play important roles in tumor progression. Although gene signatures reflecting the influence of these stresses are powerful approaches to link expression ... -
Tel1p and Mec1p Regulate Chromosome Segregation and Chromosome Rearrangements in <italic>Saccharomyces cerevisiae</italic>
(2010)Cancer cells often have elevated frequencies of chromosomal aberrations, and it is likely that loss of genome stability is one driving force behind tumorigenesis. Deficiencies in DNA replication, DNA repair, or cell cycle ...
