Browsing by Subject "Antibiotics, Antineoplastic"

Now showing items 1-2 of 2

MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy.

Balakumaran, BS; Febbo, PG; Foye, A; Glover, W; Hahn, WC; Hsu, DS; Leung, JY; ... (10 authors) (Cancer Res, 2009-10-01)

Loss of PTEN and activation of phosphoinositide 3-kinase are commonly observed in advanced prostate cancer. Inhibition of mammalian target of rapamycin (mTOR), a downstream target of phosphoinositide 3-kinase signaling, ...
The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy.

Ali, AS; Carraway, MS; Piantadosi, Claude Anthony; Reynolds, CM; Suliman, Hagir B; Welty-Wolf, KE (J Clin Invest, 2007-12)

The clinical utility of anthracycline anticancer agents, especially doxorubicin, is limited by a progressive toxic cardiomyopathy linked to mitochondrial damage and cardiomyocyte apoptosis. Here we demonstrate that ...