Browsing by Subject "Antigens, CD20"
Now showing items 1-3 of 3
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CD20 deficiency in humans results in impaired T cell-independent antibody responses.
(J Clin Invest, 2010-01)CD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs are commonly used for the treatment of B cell malignancies and autoantibody-mediated autoimmune diseases. Despite this the role of CD20 ... -
Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys.
(PLoS Pathog, 2009-12)African green monkeys (AGM) and other natural hosts for simian immunodeficiency virus (SIV) do not develop an AIDS-like disease following SIV infection. To evaluate differences in the role of SIV-specific adaptive immune ... -
Prevention trumps treatment of antibody-mediated transplant rejection.
(J Clin Invest, 2010-04)Belying the spectacular success of solid organ transplantation and improvements in immunosuppressive therapy is the reality that long-term graft survival rates remain relatively unchanged, in large part due to chronic and ...
