Browsing by Subject "Aspergillus"
Now showing items 1-14 of 14
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Blood Aspergillus PCR: The Good, the Bad, and the Ugly.
(Journal of fungi (Basel, Switzerland), 2020-01)Invasive Aspergillosis (IA) is one of the most common invasive fungal diseases and is accompanied by high morbidity and mortality. In order to maximize patient outcomes and survival, early and rapid diagnosis has been shown ... -
Breakthrough invasive fungal infections: Who is at risk?
(Mycoses, 2020-10)The epidemiology of invasive fungal infections (IFIs) in immunocompromised individuals has changed over the last few decades, partially due to the increased use of antifungal agents to prevent IFIs. Although this strategy ... -
Calcineurin Inhibitor CN585 Exhibits Off-Target Effects in the Human Fungal Pathogen Aspergillus fumigatus.
(Journal of fungi (Basel, Switzerland), 2022-12)Calcineurin (CN) is an attractive antifungal target as it is critical for growth, stress response, drug resistance, and virulence in fungal pathogens. The immunosuppressive drugs, tacrolimus (FK506) and cyclosporin A (CsA), ... -
Coronavirus Disease 2019-Associated Invasive Fungal Infection.
(Open forum infectious diseases, 2021-12)Coronavirus disease 2019 (COVID-19) can become complicated by secondary invasive fungal infections (IFIs), stemming primarily from severe lung damage and immunologic deficits associated with the virus or immunomodulatory ... -
COVID-19 Associated Pulmonary Aspergillosis (CAPA)-From Immunology to Treatment.
(Journal of fungi (Basel, Switzerland), 2020-06)Like severe influenza, coronavirus disease-19 (COVID-19) resulting in acute respiratory distress syndrome (ARDS) has emerged as an important disease that predisposes patients to secondary pulmonary aspergillosis, with 35 ... -
Immune Parameters for Diagnosis and Treatment Monitoring in Invasive Mold Infection.
(Journal of fungi (Basel, Switzerland), 2019-12)Infections caused by invasive molds, including Aspergillus spp., can be difficult to diagnose and remain associated with high morbidity and mortality. Thus, early diagnosis and targeted systemic antifungal treatment remains ... -
Improving the rates of Aspergillus detection: an update on current diagnostic strategies.
(Expert review of anti-infective therapy, 2019-01)<h4>Introduction</h4>The spectrum of disease caused by Aspergillus spp. is dependent on the immune system of the host, and ranges from invasive aspergillosis (IA) to chronic pulmonary aspergillosis (CPA). Early and reliable ... -
Invasive aspergillosis in critically ill patients: Review of definitions and diagnostic approaches.
(Mycoses, 2021-09)Invasive aspergillosis (IA) is an increasingly recognised phenomenon in critically ill patients in the intensive care unit, including in patients with severe influenza and severe coronavirus disease 2019 (COVID-19) infection. ... -
Performance of the Bronchoalveolar Lavage Fluid Aspergillus Galactomannan Lateral Flow Assay With Cube Reader for Diagnosis of Invasive Pulmonary Aspergillosis: A Multicenter Cohort Study.
(Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021-10)<h4>Background</h4>The Aspergillus Galactomannan Lateral Flow Assay (LFA) is a rapid test for the diagnosis of invasive aspergillosis (IA) that has been almost exclusively evaluated in patients with hematologic malignancies. ... -
Performance of the Euroimmun Aspergillus Antigen ELISA for the Diagnosis of Invasive Pulmonary Aspergillosis in Bronchoalveolar Lavage Fluid.
(Journal of clinical microbiology, 2022-04)Invasive pulmonary aspergillosis (IPA) is a life-threatening disease that affects mainly immunocompromised hosts. Galactomannan testing from serum and bronchoalveolar lavage fluid (BALF) represents a cornerstone in diagnosing ... -
Serum Lateral Flow assay with digital reader for the diagnosis of invasive pulmonary aspergillosis: A two-centre mixed cohort study.
(Mycoses, 2021-10)<h4>Background</h4>Detection of galactomannan (GM) from bronchoalveolar lavage fluid (BALF) or serum is broadly used for diagnosis of invasive aspergillosis (IA), although the sensitivity of GM from serum is lower ... -
Tissue-Resident Macrophages in Fungal Infections.
(Frontiers in immunology, 2017-01)Invasive fungal infections result in high morbidity and mortality. Host organs targeted by fungal pathogens vary depending on the route of infection and fungal species encountered. Cryptococcus neoformans infects the respiratory ... -
Treatment of Aspergillosis.
(Journal of fungi (Basel, Switzerland), 2018-08)Infections caused by Aspergillus spp. remain associated with high morbidity and mortality. While mold-active antifungal prophylaxis has led to a decrease of occurrence of invasive aspergillosis (IA) in those patients most ...
