Browsing by Subject "Asthma"
Now showing items 1-20 of 30
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A Heterotopic Xenograft Model of Human Airways for Investigating Fibrosis in Asthma.
(American journal of respiratory cell and molecular biology, 2017-03)Limited in vivo models exist to investigate the lung airway epithelial role in repair, regeneration, and pathology of chronic lung diseases. Herein, we introduce a novel animal model in asthma-a xenograft system integrating ... -
A novel role for primary cilia in airway remodeling.
(American journal of physiology. Lung cellular and molecular physiology, 2017-08)Primary cilia (PC) are solitary cellular organelles that play critical roles in development, homeostasis, and disease pathogenesis by modulating key signaling pathways such as Sonic Hedgehog and calcium flux. The antenna-like ... -
Airway fibroblasts in asthma manifest an invasive phenotype.
(American journal of respiratory and critical care medicine, 2011-06)<h4>Rationale</h4>Invasive cell phenotypes have been demonstrated in malignant transformation, but not in other diseases, such as asthma. Cellular invasiveness is thought to be mediated by transforming growth factor (TGF)-β1 ... -
Asthma medication usage is significantly reduced following bariatric surgery.
(Surgical endoscopy, 2019-06)<h4>Introduction</h4>Asthma is an important healthcare problem affecting millions in the United States. Additionally, a large proportion of patients with asthma suffer from obesity. These patients exhibit poor asthma control ... -
Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study.
(International journal of public health, 2023-01)Objectives: Determine the prevalence of airway disease (e.g., asthma, airflow obstruction, and eosinophilic airway inflammation) in Kenya, as well as related correlates of airway disease and health-related quality of life. ... -
Beta-arrestin-2 regulates the development of allergic asthma.
(J Clin Invest, 2003-08)Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. Migration of Th2 cells to the lung is key to their inflammatory function ... -
Characteristics of primary care and rates of pediatric hospitalizations in Brazil.
(Revista de saude publica, 2020-01)<h4>Objective</h4>To evaluate the association among characteristics of primary health care center (PHCC) with hospitalizations for primary care sensitive conditions (PCSC) in Brazil.<h4>Method</h4>In this study, a cross-sectional ... -
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
(J Immunol, 2011-03-15)Stimulated CD4(+) T lymphocytes can differentiate into effector T cell (Teff) or inducible regulatory T cell (Treg) subsets with specific immunological roles. We show that Teff and Treg require distinct metabolic programs ... -
Development of a real-world database for asthma and COPD: The SingHealth-Duke-NUS-GSK COPD and Asthma Real-World Evidence (SDG-CARE) collaboration.
(BMC medical informatics and decision making, 2023-01)<h4>Purpose</h4>The SingHealth-Duke-GlaxoSmithKline COPD and Asthma Real-world Evidence (SDG-CARE) collaboration was formed to accelerate the use of Singaporean real-world evidence in research and clinical care. A centerpiece ... -
Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma.
(Immunity, inflammation and disease, 2018-06)<h4>Rationale</h4>Patients with asthma demonstrate depletion of the endogenous bronchodilator GSNO and upregulation of GSNOR.<h4>Objectives</h4>An exploratory proof of concept clinical study of N6022 in mild asthma to determine ... -
Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease.
(Respiratory research, 2022-05-24)<h4>Background</h4>Asthma patients with comorbid obesity exhibit increased disease severity, in part, due to airway remodeling, which is also observed in mouse models of asthma and obesity. A mediator of remodeling that ... -
Exploring Associations Between Prenatal PFAS Exposure and Childhood Asthma
(2021-04-28)Per- and polyfluoroalkyl substances (PFAS) are a large class of man-made chemicals used extensively in consumer and industrial products, making them ubiquitous in the built and natural environment. These chemicals pose a ... -
Give Me Some Room to Breathe! Can Targeting SPHK2 Reduce Airway Smooth Muscle Thickening in Asthma?
(American journal of respiratory cell and molecular biology, 2020-01) -
IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies.
(The Journal of allergy and clinical immunology, 2012-10)Decades of research in animal models have provided abundant evidence to show that IL-13 is a key T(H)2 cytokine that directs many of the important features of airway inflammation and remodeling in patients with allergic ... -
Improving the Efficiency of Care for Pediatric Patients Hospitalized With Asthma.
(Hospital pediatrics, 2017-01)Asthma exacerbations are a leading cause of hospitalization among children. Despite the existence of national pediatric asthma guidelines, significant variation in care persists. At Duke Children's Hospital, we determined ... -
Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-β1 in airway fibroblasts in asthma.
(The European respiratory journal, 2014-02)Airway remodelling is a feature of asthma that contributes to loss of lung function. One of the central components of airway remodelling is subepithelial fibrosis. Interleukin (IL)-13 is a key T-helper 2 cytokine and is ... -
Is chronic asthma associated with shorter leukocyte telomere length at midlife?
(Am J Respir Crit Care Med, 2014-08-15)RATIONALE: Asthma is prospectively associated with age-related chronic diseases and mortality, suggesting the hypothesis that asthma may relate to a general, multisystem phenotype of accelerated aging. OBJECTIVES: To test ... -
Long-term dynamics of death rates of emphysema, asthma, and pneumonia and improving air quality.
(Int J Chron Obstruct Pulmon Dis, 2014)BACKGROUND: The respiratory tract is a major target of exposure to air pollutants, and respiratory diseases are associated with both short- and long-term exposures. We hypothesized that improved air quality in North Carolina ... -
Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications.
(The Journal of allergy and clinical immunology, 2018-03)<h4>Background</h4>Eosinophils are prominent in some patients with asthma and are increased in the submucosa in a subgroup of obese patients with asthma (OAs). Surfactant protein A (SP-A) modulates host responses to infectious ...
