Browsing by Subject "Astrocytes"
Now showing items 1-9 of 9
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Association between cell-mediated demyelination and astrocyte stimulation.
(Prog Brain Res, 1992) -
Astrocytes refine cortical connectivity at dendritic spines.
(Elife, 2014-12-17)During cortical synaptic development, thalamic axons must establish synaptic connections despite the presence of the more abundant intracortical projections. How thalamocortical synapses are formed and maintained in this ... -
Astrocytes: Orchestrating synaptic plasticity?
(Neuroscience, 2016-05)Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, ... -
Dectin-1 Signaling in Central Nervous System Autoimmunity
(2022)Dectin-1 is a C-type lectin receptor with diverse functions in orchestrating the innate immune response. Previous studies have primarily focused on the function of Dectin-1 in the setting of fungal infection. However, emerging ... -
Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study.
(Neural plasticity, 2016-01)Glutamatergic gliotransmission, that is, the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic ... -
Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.
(J Neurosci, 2004-05-12)Release of endogenous dynorphin opioids within the spinal cord after partial sciatic nerve ligation (pSNL) is known to contribute to the neuropathic pain processes. Using a phosphoselective antibody [kappa opioid receptor ... -
Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.
(Nature, 2013-05)Postnatal/adult neural stem cells (NSCs) within the rodent subventricular zone (SVZ; also called subependymal zone) generate doublecortin (Dcx)(+) neuroblasts that migrate and integrate into olfactory bulb circuitry. Continuous ... -
Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity.
(eLife, 2019-11-04)Alexander disease (AxD) is a fatal neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP), which supports the structural integrity of astrocytes. Over 70 GFAP missense mutations cause AxD, ... -
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
(Nature, 2012-02-15)The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) mutations in human cancers has rekindled the idea that altered cellular metabolism can transform cells. Inactivating ...
