ALERT: This system is being upgraded on Tuesday December 12. It will not be available for use for several hours that day while the upgrade is in progress. Deposits to DukeSpace will be disabled on Monday December 11, so no new items are to be added to the repository while the upgrade is in progress. Everything should be back to normal by the end of day, December 12.

Now showing items 1-5 of 5

    • Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues. 

      Johnson, Carrie E; Huang, Yolanda Y; Parrish, Amanda B; Smith, Michelle I; Vaughn, Allyson E; Zhang, Qian; Wright, Kevin M; ... (11 authors) (Proc Natl Acad Sci U S A, 2007-12-26)
      Brain tumors are typically resistant to conventional chemotherapeutics, most of which initiate apoptosis upstream of mitochondrial cytochrome c release. In this study, we demonstrate that directly activating apoptosis downstream ...
    • Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas. 

      Jin, Genglin; Reitman, Zachary J; Duncan, Christopher G; Spasojevic, Ivan; Gooden, David M; Rasheed, B Ahmed; Yang, Rui; ... (12 authors) (Cancer research, 2013-01)
      Point mutations at Arg132 of the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase 1 (IDH1) occur frequently in gliomas and result in a gain of function to produce the "oncometabolite" D-2-hydroxyglutarate (D-2HG). ...
    • GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas. 

      Majzner, Robbie G; Ramakrishna, Sneha; Yeom, Kristen W; Patel, Shabnum; Chinnasamy, Harshini; Schultz, Liora M; Richards, Rebecca M; ... (47 authors) (Nature, 2022-03)
      Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal paediatric tumours of the central nervous system1. We have previously shown that the disialoganglioside ...
    • Primary Spinal Cord Astrocytomas: Two-Center Clinical Experience of Low- and High-Grade Lesions. 

      Snyder, M Harrison; Yu-Der Wang, Andy; Ampie, Leonel; Sarathy, Danyas; Chatrath, Ajay; Asthagiri, Ashok R; Shaffrey, Christopher I; ... (15 authors) (World neurosurgery, 2022-11)
      <h4>Objective</h4>Primary spinal cord astrocytomas are rare, fatal, and poorly studied.<h4>Methods</h4>This study included a 2-center, retrospective analysis of primary spinal cord astrocytoma patients from 1997 to 2020. ...
    • Targeted radiotherapy of brain tumours. 

      Zalutsky, MR (Br J Cancer, 2004-04-19)
      The utility of external beam radiotherapy for the treatment of malignant brain tumours is compromised by the need to avoid excessive radiation damage to normal CNS tissues. This review describes the current status of targeted ...