Now showing items 1-3 of 3

    • Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues. 

      Johnson, CE; Huang, YY; Parrish, AB; Smith, MI; Vaughn, AE; Zhang, Q; Wright, KM; ... (11 authors) (Proc Natl Acad Sci U S A, 2007-12-26)
      Brain tumors are typically resistant to conventional chemotherapeutics, most of which initiate apoptosis upstream of mitochondrial cytochrome c release. In this study, we demonstrate that directly activating apoptosis downstream ...
    • Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas. 

      McLendon, Roger; Yan, Hai; Bigner, Darell; He, Yiping; Spasojevic, Ivan; Rasheed, Ahmed; Lopez, Giselle; ... (12 authors) (Cancer research, 2013-01)
      Point mutations at Arg132 of the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase 1 (IDH1) occur frequently in gliomas and result in a gain of function to produce the "oncometabolite" D-2-hydroxyglutarate (D-2HG). ...
    • Targeted radiotherapy of brain tumours. 

      Zalutsky, Michael Rod (Br J Cancer, 2004-04-19)
      The utility of external beam radiotherapy for the treatment of malignant brain tumours is compromised by the need to avoid excessive radiation damage to normal CNS tissues. This review describes the current status of targeted ...