Browsing by Subject "Autism Spectrum Disorder"
Now showing items 1-12 of 12
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A Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder.
(The Journal of pediatrics, 2020-07)<h4>Objective</h4>To evaluate whether umbilical cord blood (CB) infusion is safe and associated with improved social and communication abilities in children with autism spectrum disorder (ASD).<h4>Study design</h4>This ... -
A Window Into Autonomic Nervous System Functioning in Autism: Pupillometry in Adults on the Autism Spectrum
(2021)The autonomic nervous system (ANS) regulates physiological processes throughout the body and disruption or imbalance of that system has been associated with negative physical and psychological outcomes. Pupil responsivity ... -
Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single-Center Phase I Open-Label Trial.
(Stem cells translational medicine, 2017-05)Despite advances in early diagnosis and behavioral therapies, more effective treatments for children with autism spectrum disorder (ASD) are needed. We hypothesized that umbilical cord blood-derived cell therapies may have ... -
Cell therapy for diverse central nervous system disorders: inherited metabolic diseases and autism.
(Pediatric research, 2018-01)The concept of utilizing human cells for the treatment of medical conditions is not new. In its simplest form, blood product transfusion as treatment of severe hemorrhage has been practiced since the 1800s. The advent of ... -
Challenges in the diagnosis and treatment of depression in autism spectrum disorders across the lifespan.
(Dialogues Clin Neurosci, 2015-06)Diagnosis and treatment of comorbid neuropsychiatric illness is often a secondary focus of treatment in individuals with autism spectrum disorder (ASD), given that substantial impairment may be caused by core symptoms of ... -
De novo Blood Biomarkers in Autism: Autoantibodies against Neuronal and Glial Proteins.
(Behavioral sciences (Basel, Switzerland), 2019-04-29)Autism spectrum disorders (ASDs) are the most common neurodevelopmental disorders with unidentified etiology. The behavioral manifestations of ASD may be a consequence of genetic and/or environmental pathology in ... -
Electrophysiological Biomarkers Predict Clinical Improvement in an Open-Label Trial Assessing Efficacy of Autologous Umbilical Cord Blood for Treatment of Autism.
(Stem cells translational medicine, 2018-11)This study was a phase I, single-center, and open-label trial of a single intravenous infusion of autologous umbilical cord blood in young children with autism spectrum disorder (ASD). Twenty-five children between the ages ... -
Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression.
(Molecular autism, 2016-01)BACKGROUND:Intellectual disability (ID), autism, and epilepsy share frequent yet variable comorbidities with one another. In order to better understand potential genetic divergence underlying this variable risk, we studied ... -
Infusion of human umbilical cord tissue mesenchymal stromal cells in children with autism spectrum disorder.
(Stem cells translational medicine, 2020-10)Ongoing neuroinflammation may contribute to symptoms of autism spectrum disorder (ASD) in at least a portion of affected individuals. Mesenchymal stromal cells (MSCs) have demonstrated the capacity to modulate neuroinflammation, ... -
Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature.
(Scientific reports, 2020-07-02)Ollivier-Ricci curvature is a method for measuring the robustness of connections in a network. In this work, we use curvature to measure changes in robustness of brain networks in children with autism spectrum disorder (ASD). ... -
Stem cell therapies in cerebral palsy and autism spectrum disorder.
(Developmental medicine and child neurology, 2021-05)Across disciplines, there is great anticipation that evolving cell therapies may finally provide a therapeutic option for conditions in dire need. These conditions are typically complex and their pathophysiology incompletely ... -
White Matter Tract Changes Associated with Clinical Improvement in an Open-Label Trial Assessing Autologous Umbilical Cord Blood for Treatment of Young Children with Autism.
(Stem cells translational medicine, 2019-02)Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by social communication deficits and the presence of restricted interests and repetitive behaviors. We have previously reported ...
