Browsing by Subject "Autoimmunity"
Now showing items 1-9 of 9
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Analysis of TCR Signaling and Erk Activation in T Cell Development and Autoimmunity
(2012)<p>LAT is a transmembrane adaptor protein that is critical for the emanation of signals downstream of the TCR. Following TCR engagement, LAT is phosphorylated on multiple tyrosine residues, allowing it to serve as a scaffold ... -
Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis.
(J Autoimmun, 2014-08)Muscle specific tyrosine kinase myasthenia gravis (MuSK MG) is a form of autoimmune MG that predominantly affects women and has unique clinical features, including prominent bulbar weakness, muscle atrophy, and excellent ... -
Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2.
(J Exp Med, 2000-11-06)The complement system enhances antibody responses to T-dependent antigens, but paradoxically, deficiencies in C1 and C4 are strongly linked to autoantibody production in humans. In mice, disruption of the C1qa gene also ... -
JunB promotes Th17 cell identity and restrains alternative CD4+ T-cell programs during inflammation.
(Nature communications, 2017-08-21)T helper 17 (Th17) cell plasticity contributes to both immunity and autoimmunity; however, the factors that control lineage flexibility are mostly unknown. Here we show the activator protein-1 (AP-1) factor JunB is an essential ... -
Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.
(PLoS Med, 2009-07-07)BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks ... -
Rapid complete response of metastatic melanoma in a patient undergoing ipilimumab immunotherapy in the setting of active ulcerative colitis.
(J Immunother Cancer, 2015)While blockade of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) T cell regulatory receptor has become a commonly utilized strategy in the management of advanced melanoma, many questions remain regarding the use of this agent ... -
Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration.
(Experimental eye research, 2017-02)We report on a novel autoantigen expressed in human macular tissues, identified following an initial Western blot (WB)-based screening of sera from subjects with age-related macular degeneration (AMD) for circulating ... -
Roles of Id3 and IL-13 in a Mouse Model of Autoimmune Exocrinopathy
(2015)Within the field of immunology, the existence of autoimmune diseases presents a unique set of challenges. The immune system typically protects the host by identifying foreign pathogens and mounting an appropriate response ... -
Th17 Cell Pathogenicity Promoted by Integrin α3 During Autoimmune Neuroinflammation
(2022)Autoimmune diseases are caused by dysregulated immune responses against self. Multiple sclerosis (MS) is one such autoimmune disease in which the central nervous system (CNS) is affected by chronic inflammation, and Th17 ...
