Browsing by Subject "Axons"
Now showing items 1-20 of 20
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A polyaxonal amacrine cell population in the primate retina.
(The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014-03)Amacrine cells are the most diverse and least understood cell class in the retina. Polyaxonal amacrine cells (PACs) are a unique subset identified by multiple long axonal processes. To explore their functional properties, ... -
Axonal growth-associated proteins.
(Annual review of neuroscience, 1989-01) -
Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system.
(The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011-10)Spinal cord injury (SCI) causes permanent debilitation due to the inability of axons to grow through established scars. Both the sugar chains and core proteins of chondroitin sulfate proteoglycans (CSPGs) are inhibitory ... -
Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systems.
(The Journal of cell biology, 1981-04)In an effort to determine whether the "growth state" and the "mature state" of a neuron are differentiated by different programs of gene expression, we have compared the rapidly transported (group I) proteins in growing ... -
Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage.
(Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017-01)<h4>Background/aims</h4>Intracerebral hemorrhage (ICH) occurs in hypertensive patients and results in high rates of mortality and disability. This study determined whether bone marrow mesenchymal stem cell (BMSC) transplantation ... -
Calcineurin activation causes retinal ganglion cell degeneration.
(Mol Vis, 2012)PURPOSE: We previously reported that calcineurin, a Ca(2+)/calmodulin-dependent serine/threonine phosphatase, is activated and proposed that it participates in retinal ganglion cell (RGC) apoptosis in two rodent ... -
Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells.
(The Journal of cell biology, 1981-04)In an effort to understand the regulation of the transition of a mature neuron to the growth, or regenerating, state we have analyzed the composition of the axonally transported proteins in the retinal ganglion cells of ... -
Composition and topographic organization of signals sent from the frontal eye field to the superior colliculus.
(J Neurophysiol, 2000-04)The frontal eye field (FEF) and superior colliculus (SC) contribute to saccadic eye movement generation, and much of the FEF's oculomotor influence may be mediated through the SC. The present study examined the composition ... -
Convergent differential regulation of SLIT-ROBO axon guidance genes in the brains of vocal learners.
(J Comp Neurol, 2015-04-15)Only a few distantly related mammals and birds have the trait of complex vocal learning, which is the ability to imitate novel sounds. This ability is critical for speech acquisition and production in humans, and is attributed ... -
Developmental mechanism of the periodic membrane skeleton in axons.
(Elife, 2014-12-23)Actin, spectrin, and associated molecules form a periodic sub-membrane lattice structure in axons. How this membrane skeleton is developed and why it preferentially forms in axons are unknown. Here, we studied the developmental ... -
Enhancing the Hodgkin-Huxley Equations: Simulations Based on the First Publication in the Biophysical Journal.
(Biophys J, 2015-10-06)The experiments in the Cole and Moore article in the first issue of the Biophysical Journal provided the first independent experimental confirmation of the Hodgkin-Huxley (HH) equations. A log-log plot of the K current versus ... -
Evaluation of high-perimeter electrode designs for deep brain stimulation.
(Journal of neural engineering, 2014-08)<h4>Objective</h4>Deep brain stimulation (DBS) is an effective treatment for movement disorders and a promising therapy for treating epilepsy and psychiatric disorders. Despite its clinical success, complications including ... -
Fibroblast growth factor23 is associated with axonal integrity and neural network architecture in the human frontal lobes.
(PloS one, 2018-01)Elevated levels of FGF23 in individuals with chronic kidney disease (CKD) are associated with adverse health outcomes, such as increased mortality, large vessel disease, and reduced white matter volume, cardiovascular and ... -
Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.
(J Clin Invest, 2010-05)The folate pathway plays a crucial role in the regeneration and repair of the adult CNS after injury. Here, we have shown in rodents that such repair occurs at least in part through DNA methylation. In animals with combined ... -
Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain.
(Mol Pain, 2015-04-10)BACKGROUND: Mechanical and in particular tactile allodynia is a hallmark of chronic pain in which innocuous touch becomes painful. Previous cholera toxin B (CTB)-based neural tracing experiments and electrophysiology studies ... -
Nogo receptor 1 is expressed by nearly all retinal ganglion cells.
(PloS one, 2018-01)A variety of conditions ranging from glaucoma to blunt force trauma lead to optic nerve atrophy. Identifying signaling pathways for stimulating axon growth in the optic nerve may lead to treatments for these pathologies. ... -
Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43.
(The Journal of cell biology, 1989-02)Growth cones, the motile apparatus at the ends of elongating axons, are sites of extensive and dynamic membrane-cytoskeletal interaction and insertion of new membrane into the growing axon. One of the most abundant proteins ... -
Reversible inactivation of macaque frontal eye field.
(Exp Brain Res, 1997-09)The macaque frontal eye field (FEF) is involved in the generation of saccadic eye movements and fixations. To better understand the role of the FEF, we reversibly inactivated a portion of it while a monkey made saccades ... -
StimVision v2: Examples and Applications in Subthalamic Deep Brain Stimulation for Parkinson's Disease.
(Neuromodulation : journal of the International Neuromodulation Society, 2021-02)<h4>Objective</h4>Subthalamic deep brain stimulation (DBS) is an established therapy for Parkinson's disease. Connectomic DBS modeling is a burgeoning subfield of research aimed at characterizing the axonal connections activated ... -
The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
(Cell, 2009-09-04)Growth cone guidance and synaptic plasticity involve dynamic local changes in proteins at axons and dendrites. The Dual-Leucine zipper Kinase MAPKKK (DLK) has been previously implicated in synaptogenesis and axon outgrowth ...
