Browsing by Subject "Axons"
Now showing items 1-12 of 12
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A polyaxonal amacrine cell population in the primate retina.
(The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014-03)Amacrine cells are the most diverse and least understood cell class in the retina. Polyaxonal amacrine cells (PACs) are a unique subset identified by multiple long axonal processes. To explore their functional properties, ... -
Calcineurin activation causes retinal ganglion cell degeneration.
(Mol Vis, 2012)PURPOSE: We previously reported that calcineurin, a Ca(2+)/calmodulin-dependent serine/threonine phosphatase, is activated and proposed that it participates in retinal ganglion cell (RGC) apoptosis in two rodent ... -
Composition and topographic organization of signals sent from the frontal eye field to the superior colliculus.
(J Neurophysiol, 2000-04)The frontal eye field (FEF) and superior colliculus (SC) contribute to saccadic eye movement generation, and much of the FEF's oculomotor influence may be mediated through the SC. The present study examined the composition ... -
Convergent differential regulation of SLIT-ROBO axon guidance genes in the brains of vocal learners.
(J Comp Neurol, 2015-04-15)Only a few distantly related mammals and birds have the trait of complex vocal learning, which is the ability to imitate novel sounds. This ability is critical for speech acquisition and production in humans, and is attributed ... -
Developmental mechanism of the periodic membrane skeleton in axons.
(Elife, 2014-12-23)Actin, spectrin, and associated molecules form a periodic sub-membrane lattice structure in axons. How this membrane skeleton is developed and why it preferentially forms in axons are unknown. Here, we studied the developmental ... -
Enhancing the Hodgkin-Huxley Equations: Simulations Based on the First Publication in the Biophysical Journal.
(Biophys J, 2015-10-06)The experiments in the Cole and Moore article in the first issue of the Biophysical Journal provided the first independent experimental confirmation of the Hodgkin-Huxley (HH) equations. A log-log plot of the K current versus ... -
Fibroblast growth factor23 is associated with axonal integrity and neural network architecture in the human frontal lobes.
(PloS one, 2018-01)Elevated levels of FGF23 in individuals with chronic kidney disease (CKD) are associated with adverse health outcomes, such as increased mortality, large vessel disease, and reduced white matter volume, cardiovascular and ... -
Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.
(J Clin Invest, 2010-05)The folate pathway plays a crucial role in the regeneration and repair of the adult CNS after injury. Here, we have shown in rodents that such repair occurs at least in part through DNA methylation. In animals with combined ... -
Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain.
(Mol Pain, 2015-04-10)BACKGROUND: Mechanical and in particular tactile allodynia is a hallmark of chronic pain in which innocuous touch becomes painful. Previous cholera toxin B (CTB)-based neural tracing experiments and electrophysiology studies ... -
Nogo receptor 1 is expressed by nearly all retinal ganglion cells.
(PloS one, 2018-01)A variety of conditions ranging from glaucoma to blunt force trauma lead to optic nerve atrophy. Identifying signaling pathways for stimulating axon growth in the optic nerve may lead to treatments for these pathologies. ... -
Reversible inactivation of macaque frontal eye field.
(Exp Brain Res, 1997-09)The macaque frontal eye field (FEF) is involved in the generation of saccadic eye movements and fixations. To better understand the role of the FEF, we reversibly inactivated a portion of it while a monkey made saccades ... -
The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
(Cell, 2009-09-04)Growth cone guidance and synaptic plasticity involve dynamic local changes in proteins at axons and dendrites. The Dual-Leucine zipper Kinase MAPKKK (DLK) has been previously implicated in synaptogenesis and axon outgrowth ...
