Browsing by Subject "Bacterial Infections"
Now showing items 1-11 of 11
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Antibiotic resistance-the need for global solutions.
(Lancet Infect Dis, 2013-12)The causes of antibiotic resistance are complex and include human behaviour at many levels of society; the consequences affect everybody in the world. Similarities with climate change are evident. Many efforts have been ... -
Changing epidemiology of serious bacterial infections in febrile infants without localizing signs.
(PLoS One, 2010-08-27)OBJECTIVE: Historically, management of infants with fever without localizing signs (FWLS) has generated much controversy, with attempts to risk stratify based on several criteria. Advances in medical practice may have altered ... -
Complications of implantable venous access devices in patients with sickle cell disease.
(American journal of hematology, 2011-10)Implantable venous access devices (VADs) are used in sickle cell disease (SCD) for patients with poor venous access to facilitate chronic blood transfusions and manage acute complications. We attempted to define the frequency ... -
Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test.
(Critical care medicine, 2021-10)<h4>Objectives</h4>Host gene expression signatures discriminate bacterial and viral infection but have not been translated to a clinical test platform. This study enrolled an independent cohort of patients to describe and ... -
Etiologies of illness among patients meeting integrated management of adolescent and adult illness district clinician manual criteria for severe infections in northern Tanzania: implications for empiric antimicrobial therapy.
(Am J Trop Med Hyg, 2015-02)We describe the laboratory-confirmed etiologies of illness among participants in a hospital-based febrile illness cohort study in northern Tanzania who retrospectively met Integrated Management of Adolescent and Adult Illness ... -
Etiology of severe non-malaria febrile illness in Northern Tanzania: a prospective cohort study.
(PLoS Negl Trop Dis, 2013)INTRODUCTION: The syndrome of fever is a commonly presenting complaint among persons seeking healthcare in low-resource areas, yet the public health community has not approached fever in a comprehensive manner. In many areas, ... -
Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.
(PLoS One, 2007-10-10)BACKGROUND: Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. ... -
Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection.
(JAMA network open, 2022-04)<h4>Importance</h4>Bacterial and viral causes of acute respiratory illness (ARI) are difficult to clinically distinguish, resulting in the inappropriate use of antibacterial therapy. The use of a host gene expression-based ... -
Systematic comparison of published host gene expression signatures for bacterial/viral discrimination.
(Genome medicine, 2022-02-21)<h4>Background</h4>Measuring host gene expression is a promising diagnostic strategy to discriminate bacterial and viral infections. Multiple signatures of varying size, complexity, and target populations have been described. ... -
Validation of a Host Gene Expression Test for Bacterial/Viral Discrimination in Immunocompromised Hosts.
(Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021-08)<h4>Background</h4>Host gene expression has emerged as a complementary strategy to pathogen detection tests for the discrimination of bacterial and viral infection. The impact of immunocompromise on host-response tests remains ... -
WHO guidelines for antimicrobial treatment in children admitted to hospital in an area of intense Plasmodium falciparum transmission: prospective study.
(BMJ, 2010-03-30)OBJECTIVES: To assess the performance of WHO's "Guidelines for care at the first-referral level in developing countries" in an area of intense malaria transmission and identify bacterial infections in children with and without ...
