Browsing by Subject "Bioengineering"
Now showing items 1-12 of 12
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Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.
(Elife, 2015-01-09)Existing in vitro models of human skeletal muscle cannot recapitulate the organization and function of native muscle, limiting their use in physiological and pharmacological studies. Here, we demonstrate engineering ... -
Bioinformatics and Molecular Approaches for the Construction of Biological Artificial Cartilage
(2018)Osteoarthritis (OA) is one of the leading causes of disability in the United States, afflicting over 27 million Americans and imposing an economic burden of more than $128 billion each year (1, 2). OA is characterized by ... -
Blast-Induced Neurotrauma and the Cavitation Mechanism of Injury
(2019)Traumatic brain injuries (TBIs) are a major public health concern and socioeconomic burden worldwide. In recent years, brain injuries in US service personnel have focused attention on TBI affecting the military population ... -
Development of a Self-Focusing Multi-Spark Shock Wave Generator for Lithotripsy
(2018)In this thesis, a self-focusing multi-spark (SFMS) shock wave generator is developed to provide flexibility in controlling the beam size and shape in an electrohydraulic shock wave lithotripter. Such a device will allow ... -
Development of Novel Antibody-Based Immunotherapies Targeting Human Chondroitin Sulfate Proteoglycan 4
(2018)Chondroitin sulfate proteoglycan 4 (CSPG4) is a promising target for cancer immunotherapy due to its high level of expression in a number of malignant tumors, and its essential role in tumor growth and progression. Clinical ... -
Development of Tunable Molecular Tension Sensors to Visualize Vinculin Loading and Detect Mechanosensitive Protein Recruitment to Focal Adhesions
(2018)Mechanical forces are potent drivers of many biological processes. The form and function of many tissues depends on cells receiving the proper mechanical signals either from neighboring cells or from the underlying matrix. ... -
Genome-wide Metabolic Reconstruction and Flux Balance Analysis Modeling of Haloferax volcanii
(2018)The Archaea are an understudied domain of the tree of life, and consist of single-celled microorganisms possessing rich metabolic diversity. Archaeal metabolic capabilities are of interest for industry and basic understanding ... -
In Vitro Calcium Imaging of Magnetogenetic Ion Channels TRPV1FeRIC and TRPV4FeRIC
(2018)Ferritin-based magnetogenetic ion channels are promising new tools for non-invasive manipulation of ion channel activity. The use of these channels in animals has been promising but in vitro experiments in cultured cells ... -
Intrinsically Disordered Protein Polymer Libraries as Tools to Understand Protein Hydrophobicity
(2019)Intrinsically disordered protein polymers (IDPPs) are repetitive biopolymers that, when enriched with prolines, glycines, and aliphatic amino acids, have observable lower critical solution temperature (LCST) phase transition ... -
Molecular and Biofunctional Modification of Conformal POEGMA Bottlebrush Coatings and Applications Toward In Vitro Diagnostics
(2019)In vitro diagnostic assays (IVDs) play a crucial role in modern biomedical research and clinical decision-making. The overall performance and cost of IVDs depends considerably on the quality of the assay surface being used ... -
Novel Algorithms and Tools for Computational Protein Design with Applications to Drug Resistance Prediction, Antibody Design, Peptide Inhibitor Design, and Protein Stability Prediction
(2019)Proteins are biological macromolecules made up of amino acids. Proteins range from enzymes to antibodies and perform their functions through a variety of mechanisms, including through protein-protein interactions (PPIs). ... -
Validating the Use of Boron Nanoparticles to Quantify Tumor Oxygen Tension in Irradiated Breast Tumors
(2019)Although hypoxia in tumors has long been identified as a key contributor to poor patient outcome, clinical solutions to lessen its deleterious effects have not been forthcoming. One reason is that there have been few means ...
