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Browsing by Subject "Biology, Bioinformatics"
Now showing items 1-19 of 19
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A Bayesian Hierarchical Model with SNP-level Functional Priors Applied to a Pathway-wide Association Study.
(2010)Tremendous effort has been put into study of the etiology of complexdiseases including the breast cancer, type 2 diabetes,cardiovascular diseases, and prostate cancers. Despite large numbers of reported disease-associated ... -
Analysis and Error Correction in Structures of Macromolecular Interiors and Interfaces
(2009)As of late 2009, the Protein Data Bank (PDB) has grown to contain over 70,000 models. This recent increase in the amount of structural data allows for more extensive explication of the governing principles of macromolecular ... -
Automated Microscopy and High Throughput Image Analysis in Arabidopsis and Drosophila
(2009)Development of a single cell into an adult organism is accomplished through an elaborate and complex cascade of spatiotemporal gene expression. While methods exist for capturing spatiotemporal expression patterns---in situ ... -
Characterization of Gene Interaction and Assessment of Ld Matrix Measures for the Analysis of Biological Pathway Association
(2009)Leukotrienes are arachidonic acid derivatives long known for their inflammatory properties and their involvement with a number of human diseases, most notably asthma. Recently, leukotriene-based inflammation has also been ... -
Computational Methods to Study Diversification in Pathogens, and Invertebrate and Vertebrate Immune Systems
(2010)Pathogens and host immune systems use strikingly similar methods of diversification. Mechanisms such as point mutations and recombination help pathogens escape the host immune system and similar mechanisms help the host ... -
Computational Molecular Engineering Nucleic Acid Binding Proteins and Enzymes
(2010)Interactions between nucleic acid substrates and the proteins and enzymes that bind and catalyze them are ubiquitous and essential for reading, writing, replicating, repairing, and regulating the genomic code by the proteomic ... -
Computer Aided Detection of Masses in Breast Tomosynthesis Imaging Using Information Theory Principles
(2008-09-18)Breast cancer screening is currently performed by mammography, which is limited by overlying anatomy and dense breast tissue. Computer aided detection (CADe) systems can serve as a double reader to improve radiologist ... -
Detecting Changes in Alternative mRNA Processing From Microarray Expression Data
(2010)Alternative mRNA processing can result in the generation of multiple, qualitatively different RNA transcripts from the same gene and is a powerful engine of complexity in higher organisms. Recent deep sequencing studies ... -
Localized Correlation Analysis and Genetic Association with Cardiovascular Disease
(2010)Variations in gene expression are potential risk factors for atherosclerosis, which is one of the most common forms of cardiovascular disease. We performed a localized Pearson correlation test in 372 individuals from seven ... -
Mechanistic and Genetic Biases in Human Immunoglobulin Heavy Chain Development
(2008-04-23)Broadly neutralizing antibodies against HIV are rare; most patients never develop them at detectable levels. The discovery of four such antibodies therefore warrants research into their origins and their presumed unique ... -
Modeling Cancer Progression on the Pathway Level
(2008-12-11)Over the past several decades, many genes have been discovered that govern important functions in the development of a variety of different cancers. However, biological insight from the list of genes is still limited and ... -
Modeling Multi-factor Binding of the Genome
(2010)Hundreds of different factors adorn the eukaryotic genome, binding to it in large number. These DNA binding factors (DBFs) include nucleosomes, transcription factors (TFs), and other proteins and protein complexes, such ... -
Protein-DNA Binding: Discovering Motifs and Distinguishing Direct from Indirect Interactions
(2009)The initiation of two major processes in the eukaryotic cell, gene transcription and DNA replication, is regulated largely through interactions between proteins or protein complexes and DNA. Although a lot is known about ... -
Regulation of Global Transcription Dynamics During Cell Division and Root Development
(2009)The successful completion of many critical biological processes depends on the proper execution of complex spatial and temporal gene expression programs. With the advent of high-throughput microarray technology, it is now ... -
RNA Backbone Rotamers and Chiropraxis
(2007-07-25)RNA backbone is biologically important with many roles in reactions and interactions, but has historically been a challenge in structural determination. It has many atoms and torsions to place, and often there is less data ... -
Studies into Location-specific cis-Regulatory Motifs
(2010)Gene expression and regulation are major determinants of phenotypic traits displayed across species. Although the DNA sequence elements that control gene expression play a crucial role in determining species morphology, ... -
Studies on Human Chromatin Using High-Throughput DNaseI Sequencing
(2009)Cis-elements govern the key step of transcription to regulate gene expression within a cell. Identification of utilized elements within a particular cell line will help further our understanding of individual and cumulative ... -
The Geometry of Cancer
(2009)Cancer is a complex, multifaceted disease that operates through dynamic changes in the genome. Cancer is best understood through the process that generates it -- random mutations operated on by natural selection -- and ... -
Using Genome-wide Approaches to Characterize the Relationship Between Genomic Variation and Disease: A Case Study in Oligodendroglioma and Staphylococcus arueus
(2010)Genetic variation is a natural occurrence in the genome that contributes to the phenotypic differences observed between individuals as well as the phenotypic outcomes of various diseases, including infectious disease and ...
