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Browsing by Subject "Biology, Cell"
Now showing items 1-20 of 44
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A Mechanism and Pro-migratory Function for Non-canonical TGF-beta Signaling through Smad1 and Smad5
(2008-12-10)During the course of breast cancer progression, normally dormant tumor-promoting effects of transforming growth factor-beta (TGF-beta) including migration, invasion, and metastasis are unmasked. Although this switch or ... -
A Paradoxical Role for PTEN in the Cellular Response to Hypoxia
(2010)Regulation of cell growth is controlled by a variety of factors, including a number of oncogenes and tumor suppressors. PTEN is an inositol phosphatase that regulates cell growth by hydrolyzing the phospholipid products ... -
Activation of developmental signaling pathways in hematopoietic stem cell regeneration
(2010)The homeostatic hematopoietic stem cell compartment is comprised of quiescent long term self renewing stem cells and cycling short term stem cells with finite renewal potential. To study the molecular mechanisms governing ... -
Adenylyl Cyclase Cell Signaling as a Target and Underlying Mechanism for Persistent Effects of Early-Life Organophosphate Exposure
(2010)Organophosphates (OPs) are developmental neurotoxicants but also produce lasting effects on metabolism. This dissertation examines the cellular mechanisms underlying metabolic dysfunction after early-life OP exposure. ... -
Building Gene Regulatory Networks in Development: Deploying Small GTPases
(2007-02-19)GTPases are integral components of virtually every known signal transduction pathway, and mutations in GTPases frequently cause disease. A genomic analysis identified and annotated 174 GTPases in the sea urchin genome (with ... -
Cancer Stem Cells in Brain Tumors: Identification of Critical Biological Effectors
(2010)Human cancer is a leading cause of morbidity and mortality in the developed world. Contrary to the classical model in which tumors are homogeneously composed of malignant cells, accumulating evidence suggests that subpopulations ... -
Cell Polarity Establishment in the Budding Yeast Saccharomyces Cerevisiae
(2009)Establishing an axis of cell polarity is central to cell motility, tissue morphogenesis, and cell proliferation. A highly conserved group of polarity regulators is responsible for organizing a wide variety of polarized ... -
Cellular Trafficking and Activation within Lymph Nodes: Contributions to Immunity and Pathogenic or Therapeutic Implications
(2010)Lymph nodes are organs of efficiency. Once activated, they essentially function to optimize and accelerate the production of the adaptive immune response, which has the potential to determine survival of the host during ... -
Characterization of the Novel Telomere Associated Protein: hSnm1B
(2008-04-10)Telomeres are the ends of chromosomes which are composed of repetitive DNA sequence and telomere associated proteins. In C. elegans, the protein F39H2.5 was found to associate with the telomere, regulating both telomere ... -
Chlamydia Subversion of Host Lipid Transport: Interactions with Cytoplasmic Lipid Droplets
(2009)The <italic>Chlamydiaceae</italic> are Gram-negative, obligate intracellular bacteria that are significant pathogens of humans and animals. Intracellularly, the bacteria reside in a membrane-bound vacuole, called the inclusion, ... -
Cryptococcus Neoformans Interactions with Surfactant Proteins: Implications for Innate Pulmonary Immunity
(2009)Concurrent with the global escalation of the AIDS pandemic, cryptococcal infections are increasing and are of significant medical importance. Although improvements in antifungal therapy have advanced the treatment ... -
Defining Roles for Cyclin Dependent Kinases and a Transcriptional Oscillator in the Organization of Cell-Cycle Events
(2009)The cell cycle is a series of ordered events that culminates in a single cell dividing into two daughter cells. These events must be properly coordinated to ensure the faithful passage of genetic material. How cell cycle ... -
Distinct Functions and Regulation of Nonmuscle Myosin II Isoforms a and B in Cell Motility
(2008-04-23)The ability of cells to migrate is of fundamental importance to a diverse array of biological processes, both physiological and pathological, such as development, the immune response and cancer cell metastasis, to name a ... -
Establishment and Regulation of Silenced Chromatin in Saccharomyces Cerevisiae
(2009)Heterochromatin, or condensed chromatin, is a transcriptionally repressive form of chromatin that occurs in many eukaryotic organisms. At its natural locations, heterochromatin is thought to play important roles in genome ... -
Function of Phosphatidylinositol 3-Kinase Class III in the Nervous System
(2010)Neurons, with their enormous membrane contents, depend heavily on regulated membrane trafficking processes to maintain their morphology and function. The phosphatidylinositol 3-kinase class III, or PIK3C3, plays a critical ... -
Function of the Mouse PIWI Proteins and Biogenesis of Their piRNAs in the Male Germline
(2009)PIWI proteins belong to an evolutionary conserved protein family as the sister sub-family of ARGONAUTE (AGO) proteins. While AGO proteins are functionally well-characterized and shown to mediate small-RNA guided gene regulation, ... -
Functional Analysis of the Cordon-bleu Protein in Mouse
(2009)The actin cytoskeleton is a fundamental component of the cell and is involved in many processes, including cell division, cell migration, vesicle trafficking and cell polarity. The actin cytoskeleton has a very important ... -
Hijacking Germ Cells for Cancer: Examining a 'Dead End' in Male Germ Cell Development
(2010)Germ cells represent the immortal line: they are guardians of a totipotent genome and are essential for the genetic survival of an individual organism and ultimately a species. An error at any stage in development ... -
Identification of Essential Functions of GRP94 in Metazoan Growth Control and Epithelial Homeostasis
(2009)GRP94, the endoplasmic reticulum Hsp90, is a metazoan-restricted chaperone essential for early development in mammals, yet dispensable for mammalian cell viability. These data suggest that GRP94 is required for important ... -
Identification of Transforming Growth Factor-beta as an Extracellular Signal Required for Axon Specification in Embryonic Brain Development
(2009)The specification of a single axon and multiple dendrites is the first observable event during neuronal morphogenesis and such structural specialization underlies neural connectivity and nervous system function. Numerous ...
